Hepatitis e virus

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Abstract

Hepatitis E presents with the typical clinical and morphologic features of acute hepatitis. Discovered in 1990, hepatitis E virus (HEV) is now recognised as the agent responsible for nearly all enterically transmitted non-A, non-B hepatitis. Hepatitis E is principally the result of water borne infection and while large-scale outbreaks have been reported in several developing countries, sporadic cases can occur in developed countries where the seroprevalence is around 1%. Acute hepatitis E infection, like hepatitis A, is an acute, self-limiting infection that may vary in severity from subclinical (more likely in children) to fulminant hepatitis. The incubation period is approximately 40 days (range 15-60 days). The death rate of patients infected with HEV is <1%, however, the mortality from HEV in pregnant patients is high (around 20%) for reasons which remain unclear. The diagnosis of acute hepatitis E relies on serology and molecular testing for HEV RNA.

Original languageEnglish
Title of host publicationPCR for Clinical Microbiology: An Australian and International Perspective
PublisherSpringer
Pages261-263
Number of pages3
ISBN (Print)9789048190386
DOIs
Publication statusPublished - 2010
Externally publishedYes

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