Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2

Esteban Gurzov, Melanie Tran, Manuel Alejandro Fernandez-Rojo, Troy Merry, Xinmei Zhang, Yang Wu, Atsushi Fukushima, Michael J Waters, Matthew J Watt, Sofianos Andrikopoulos, Benjamin G Neel, Tony Tiganis

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Hepatic insulin resistance is a key contributor to the pathogenesis of obesity and type 2 diabetes (T2D). Paradoxically, the development of insulin resistance in the liver is not universal, but pathway selective, such that insulin fails to suppress gluconeogenesis but promotes lipogenesis, contributing to the hyperglycemia, steatosis, and hypertriglyceridemia that underpin the deteriorating glucose control and microvascular complications in T2D. The molecular basis for the pathway-specific insulin resistance remains unknown. Here we report that oxidative stress accompanying obesity inactivates protein-tyrosine phosphatases (PTPs) in the liver to activate select signaling pathways that exacerbate disease progression. In obese mice, hepatic PTPN2 (TCPTP) inactivation promoted lipogenesis and steatosis and insulin-STAT-5 signaling. The enhanced STAT-5 signaling increased hepatic IGF-1 production, which suppressed central growth hormone release and exacerbated the development of obesity and T2D. Our studies define a mechanism for the development of selective insulin resistance with wide-ranging implications for diseases characterized by oxidative stress.
Original languageEnglish
Pages (from-to)85 - 102
Number of pages18
JournalCell Metabolism
Volume20
Issue number1
DOIs
Publication statusPublished - 2014

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