TY - JOUR
T1 - Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection
AU - Kaukonen, Kirsi-Maija
AU - Linko, Rita
AU - Herwald, Heiko
AU - Lindbom, Lennart
AU - Ruokonen, Esko
AU - Ala-Kokko, Tero
AU - Pettila, Ville Yrjo Olavi
PY - 2013
Y1 - 2013
N2 - Heparin-binding protein (HBP) is an inducer of vascular endothelial leakage in severe infections. Fluid accumulation into alveoli is a general finding in acute respiratory distress syndrome (ARDS). Severe acute respiratory failure with ARDS is a complication of influenza A(H1N1) infection. Accordingly, we studied the HBP levels in critically ill patients with infection of influenza A(H1N1).Critically ill patients in four intensive care units (ICUs) with polymerase chain reaction (PCR) confirmed infection of influenza A(H1N1) were prospectively evaluated. We collected clinical data and blood samples at ICU admission and on day 2. Twenty-nine patients participated in the study. Compared with normal plasma levels, the HBP concentrations were highly elevated at baseline and at day 2: 98 ng/mL (62-183 ng/mL) and 93 ng/mL (62-271 ng/mL) (p 0.876), respectively. HBP concentrations were correlated with the lowest ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen (PF ratio) during the ICU stay (rho = -0.321, p
AB - Heparin-binding protein (HBP) is an inducer of vascular endothelial leakage in severe infections. Fluid accumulation into alveoli is a general finding in acute respiratory distress syndrome (ARDS). Severe acute respiratory failure with ARDS is a complication of influenza A(H1N1) infection. Accordingly, we studied the HBP levels in critically ill patients with infection of influenza A(H1N1).Critically ill patients in four intensive care units (ICUs) with polymerase chain reaction (PCR) confirmed infection of influenza A(H1N1) were prospectively evaluated. We collected clinical data and blood samples at ICU admission and on day 2. Twenty-nine patients participated in the study. Compared with normal plasma levels, the HBP concentrations were highly elevated at baseline and at day 2: 98 ng/mL (62-183 ng/mL) and 93 ng/mL (62-271 ng/mL) (p 0.876), respectively. HBP concentrations were correlated with the lowest ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen (PF ratio) during the ICU stay (rho = -0.321, p
UR - http://onlinelibrary.wiley.com/doi/10.1111/1469-0691.12156/pdf
UR - https://www.scopus.com/pages/publications/84888069665
U2 - 10.1111/1469-0691.12156
DO - 10.1111/1469-0691.12156
M3 - Article
SN - 1198-743X
VL - 19
SP - 1122
EP - 1128
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 12
ER -