Hemostatic analysis of a 13 year old with antiphospholipid syndrome and restrictive pericarditis

Vance G. Nielsen, Brad L. Steenwyk, Thomas M. Burch, Colin K. King, David C. McGiffin

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Abstract

Antiphospholipid syndrome is an autoimmune thrombophilic disorder that is uncommon in adults and remarkably rare in children. Thrombotic etiological factors are variable in antiphospholipid syndrome, including antibody-antigen complex-mediated platelet activation, inhibition of anticoagulants, or attenuation of fibrinolysis. We present the case of a child with antiphospholipid syndrome presenting with syncope, constrictive pericarditis and hepatic enlargement that was found to have platelet-mediated hypercoagulability and marked clot lysis via thrombelastography in the preoperative period. Restoration of circulation following pericardectomy and inotropic support was associated with attenuation of hypercoagulability and fibrinolysis. It is concluded that the etiological factors responsible for antiphospholipid syndrome-mediated hemostatic abnormalities and the probable effects of hepatic hypoperfusion on clot lysis in this patient were detected with thrombelastography, and similar thrombelastographic analyses are recommended to compliment standard coagulation assessments of patients with antiphospholipid syndrome.

Original languageEnglish
Pages (from-to)695-697
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume18
Issue number7
DOIs
Publication statusPublished - 1 Oct 2007
Externally publishedYes

Keywords

  • Antiphospholipid syndrome
  • Fibrinolysis
  • Hypercoagulability
  • Pericarditis
  • Thrombelastography
  • Thrombosis

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