Hemorrhage induces c-fos immunoreactivity in spinally projecting neurons of cat subretrofacial nucleus

R. M. McAllen, E. Badoer, A. D. Shafton, B. J. Oldfield, M. J. McKinley

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Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximately 25% blood volume from a carotid cannula, 48-62% of SRF-spinal neurons expressed c-fos immunoreactivity. In 2 control animals, the corresponding values were 2% and 4%. The data show that bulbospinal neurons of presumed vasomotor function express c-fos in response to hemorrhage.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalBrain Research
Issue number2
Publication statusPublished - 20 Mar 1992
Externally publishedYes


  • Blood pressure
  • C-fos
  • Hemorrhage
  • Vasomotor pathway
  • Ventrolateral medulla

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