Hemofiltration as an adjunct to therapy for sepsis is now 10 years old. Despite early successes and significant theoretical advantages, the treatment remains experimental. Although feasibility has been established, efficacy has proved to be much more difficult. Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed.
- Continuous venovenous hemodialysis
- Continuous venovenous hemofiltration
- Multiple-organ failure
- Systemic inflammatory response syndrome