Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

Matthew R Olson, Shirley G K Seah, Jolie G. Cullen, Marie Greyer, Kathryn M. Edenborough, Peter C Doherty, Sammy Bedoui, Andrew M Lew, Stephen J. Turner

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains unclear whether induction of CD4+ Th responses postinfection are also dependent on CD4+ T cell help. In this study, we show that activation of adoptively transferred Th cells during primary influenza A virus (IAV) infection enhances both the magnitude and functional breadth of endogenous primary IAV-specific CD4+ T cell responses. This enhancement was dependent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of IAV-specific CD4+ and CD8+ T memory responses after heterologous IAV infection. These data suggest that engaging pre-existing CD4 responses at the time of priming may be a strategy for improving cellular immunity after vaccination.

Original languageEnglish
Pages (from-to)5420-5433
Number of pages14
JournalJournal of Immunology
Volume193
Issue number11
DOIs
Publication statusPublished - 1 Dec 2014
Externally publishedYes

Cite this

Olson, Matthew R ; Seah, Shirley G K ; Cullen, Jolie G. ; Greyer, Marie ; Edenborough, Kathryn M. ; Doherty, Peter C ; Bedoui, Sammy ; Lew, Andrew M ; Turner, Stephen J. / Helping themselves : Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells. In: Journal of Immunology. 2014 ; Vol. 193, No. 11. pp. 5420-5433.
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abstract = "Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains unclear whether induction of CD4+ Th responses postinfection are also dependent on CD4+ T cell help. In this study, we show that activation of adoptively transferred Th cells during primary influenza A virus (IAV) infection enhances both the magnitude and functional breadth of endogenous primary IAV-specific CD4+ T cell responses. This enhancement was dependent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of IAV-specific CD4+ and CD8+ T memory responses after heterologous IAV infection. These data suggest that engaging pre-existing CD4 responses at the time of priming may be a strategy for improving cellular immunity after vaccination.",
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Olson, MR, Seah, SGK, Cullen, JG, Greyer, M, Edenborough, KM, Doherty, PC, Bedoui, S, Lew, AM & Turner, SJ 2014, 'Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells' Journal of Immunology, vol. 193, no. 11, pp. 5420-5433. https://doi.org/10.4049/jimmunol.1303359

Helping themselves : Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells. / Olson, Matthew R; Seah, Shirley G K; Cullen, Jolie G.; Greyer, Marie; Edenborough, Kathryn M.; Doherty, Peter C; Bedoui, Sammy; Lew, Andrew M; Turner, Stephen J.

In: Journal of Immunology, Vol. 193, No. 11, 01.12.2014, p. 5420-5433.

Research output: Contribution to journalArticleResearchpeer-review

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