Abstract
Infection is a major risk factor for cancer. A leading cause of infection-attributable cancer is the gastric pathogen, Helicobacter pylori. This bacterium, together with seven viruses and three trematode parasites, are now recognized to be group I carcinogens by the International Agency for Research on Cancer. Chronic infection with these microorganisms causes inflammation, a hallmark of cancer. H. pylori infection has become a paradigm for infectious agents that promote chronic inflammation and cancer. This chapter will provide a historical perspective on the discoveries that led to this paradigm. It will also review the bacterial, host, and environmental factors involved in H. pylori-induced gastric cancer.
| Original language | English |
|---|---|
| Title of host publication | Research and Clinical Applications of Targeting Gastric Neoplasms |
| Editors | Brendan J. Jenkins |
| Place of Publication | United Kingdom |
| Publisher | Academic Press |
| Chapter | 4 |
| Pages | 91-118 |
| Number of pages | 28 |
| ISBN (Electronic) | 9780323855631 |
| DOIs | |
| Publication status | Published - 2021 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cag pathogenicity island
- CagA
- Dysbiosis
- Gastric adenocarcinoma
- Gastric microbiota
- Gene polymorphisms
- Helicobacter pylori
- Innate immunity
- Iron deficiency
- Secretion system
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