TY - JOUR
T1 - Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer
AU - Gorrell, Rebecca J
AU - Zwickel, Nicolas
AU - Reynolds, John
AU - Bulach, Dieter M
AU - Kwok, Terry
PY - 2016
Y1 - 2016
N2 - Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL protein hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.
AB - Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL protein hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.
UR - http://www.ncbi.nlm.nih.gov/pubmed/26908724
U2 - 10.1093/infdis/jiw060
DO - 10.1093/infdis/jiw060
M3 - Article
SN - 0022-1899
VL - 213
SP - 1927
EP - 1931
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
IS - 12
ER -
