Hedgehog signalling in Drosophila and vertebrate development

Peter D. Currie, Antonio Jacinto, Phillip W. Ingham

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The hedgehog (hh) gene family encode secreted proteins that are involved in a number of developmental processes in vertebrates and invertebrates. These include the patterning of the vertebrate neural tube, somites, limb and brain and the Drosophila embryonic epidermis and larval imaginal discs. Hh proteins show a high degree of sequence identity within and between species. Recent analysis has demonstrated that this family of molecules may act in a mechanistically similar way to provide positional signalling within different phyla.

Original languageEnglish
Pages (from-to)97-114
Number of pages18
JournalNetherlands Journal of Zoology
Volume46
Issue number1-2
Publication statusPublished - Jul 1996
Externally publishedYes

Keywords

  • Evolution
  • Hedgehog
  • Morphogenesis

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