TY - JOUR
T1 - Heavy menstrual bleeding and dysmenorrhea are improved by magentic resonance guided focused ultrasound surgery (mrgfus) of adenomyosis
AU - Jayaram, Ramya
AU - Subbarayan, Kalpana
AU - Mithraprabhu, Sridurga
AU - Govindarajan, Mirudhubashini
PY - 2016/5
Y1 - 2016/5
N2 - Background: To assess reduction in heavy menstrual bleeding and dysmenorrhea following MRI guided Focused Ultrasound Surgery (MRgFUS) of focal and diffuse adenomyosis up to 12 months post-treatment a retrospective cohort study was done at a tertiary care academic medical center for obstetrics, gynecology and infertility.
Methods: MRgFUS for adenomyosis uterus was done for thirty-seven patients presenting with symptoms ofheavy menstrual bleeding and dysmenorrhea with MRI-suspected adenomyosis. The main outcome measure,was reduction in heavy menstrual bleeding, dysmenorrhea and Symptom Severity Scoring (SSS) over a 3, 6 and 12 month period. Secondary outcome was evidence of fertility preservation post procedure. D’Agostino &Pearson omnibus normality test, one-way Ananova, Pearson’s correlation coefficient analysis was performed on the data. Statistical significances, p-value and r-value were determined.
Results: Out of 37 patients who were treated by MRgFUS, 26 had sufficient follow-up to be included in the analysis. SSS calculated at 3, 6 and 12 months was significantly over the baseline. Both heavy menstrual bleeding and dysmenorrhea, which were assessed separately, were found to significantly improve over time with a positive correlation between the two. No other intervention was required.
Conclusion: MRgFUS provides immediate and sustained relief for patients with focal and diffuse adenomyosis.
AB - Background: To assess reduction in heavy menstrual bleeding and dysmenorrhea following MRI guided Focused Ultrasound Surgery (MRgFUS) of focal and diffuse adenomyosis up to 12 months post-treatment a retrospective cohort study was done at a tertiary care academic medical center for obstetrics, gynecology and infertility.
Methods: MRgFUS for adenomyosis uterus was done for thirty-seven patients presenting with symptoms ofheavy menstrual bleeding and dysmenorrhea with MRI-suspected adenomyosis. The main outcome measure,was reduction in heavy menstrual bleeding, dysmenorrhea and Symptom Severity Scoring (SSS) over a 3, 6 and 12 month period. Secondary outcome was evidence of fertility preservation post procedure. D’Agostino &Pearson omnibus normality test, one-way Ananova, Pearson’s correlation coefficient analysis was performed on the data. Statistical significances, p-value and r-value were determined.
Results: Out of 37 patients who were treated by MRgFUS, 26 had sufficient follow-up to be included in the analysis. SSS calculated at 3, 6 and 12 months was significantly over the baseline. Both heavy menstrual bleeding and dysmenorrhea, which were assessed separately, were found to significantly improve over time with a positive correlation between the two. No other intervention was required.
Conclusion: MRgFUS provides immediate and sustained relief for patients with focal and diffuse adenomyosis.
KW - MRI guided Focussed Ultrasound Surgery (MRgFUS)
KW - Adenomyosis
KW - Uterus sparing surgery
KW - Fertility preservation
UR - https://fertilityresearchandpractice.biomedcentral.com/articles/10.1186/s40738-016-0021-x
U2 - 10.1186/s40738-016-0021-x
DO - 10.1186/s40738-016-0021-x
M3 - Article
C2 - 28620535
VL - 2
JO - Fertility Research and Practice
JF - Fertility Research and Practice
SN - 2054-7099
M1 - 8
ER -