Heat stress response of somatic cells in the testis

Rashid A. Aldahhan, Peter G. Stanton

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)


The testis is a temperature-sensitive organ that needs to be maintained 2–7 °C below core body temperature to ensure the production of normal sperm. Failure to maintain testicular temperature in mammals impairs spermatogenesis and leads to low sperm counts, poor sperm motility and abnormal sperm morphology in the ejaculate. This review discusses the recent knowledge on the response of testicular somatic cells to heat stress and, specifically, regarding the relevant contributions of heat, germ cell depletion and inflammatory reactions on the functions of Sertoli and Leydig cells. It also outlines mechanisms of testicular thermoregulation, as well as the thermogenic factors that impact testicular function.

Original languageEnglish
Article number111216
Number of pages13
JournalMolecular and Cellular Endocrinology
Publication statusPublished - 1 May 2021


  • Cryptorchidism
  • Heat stress
  • Leydig cell
  • Sertoli cell
  • Spermatogenesis

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