Heart Development and Regeneration

Nadia Alicia Rosenthal, Richard P Harvey

Research output: Book/ReportEdited BookOther

Abstract

It has now been a decade since our book Heart Development was published, and the field has again exploded. A more integrated picture of development, physiology and disease is emerging from our deeper investigations of the genes, proteins and cells, and the functional interactions between them, which build the cardiovascular system. This picture has been immeasurably enhanced by our explorations across the evolutionary landscape. Ten years ago, only a handful of cardiovascular malformations, the most common type of birth defect, could be associated with causative factors, but recent studies have uncovered the genetic basis of many more, and with the advent of forward mutagenic screens in fish and mice, genome-wide association studies in humans, and next generation sequencing, these investigations are now set on an entirely new course, with implications for genetic testing, counseling, long-term patient follow up and choice of intervention.....
Original languageEnglish
Place of PublicationUK
PublisherAcademic Press
Number of pages998
VolumeI and II
Edition1st
ISBN (Print)9780123813329
Publication statusPublished - 2010

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