Health-related quality of life in Australasian survivors of H1N1 influenza undergoing mechanical ventilation. A multicenter cohort study

Elizabeth Skinner, Kimberley Haines, Belinda Duval Howe, Carol Lynette Hodgson, Linda Denehy, Colin McArthur, Daniel Seller, Emma DiMarco, Kate Elizabeth Mulvany, Danielle Ryan, Sue Berney

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7 Citations (Scopus)


Rationale Patients surviving acute respiratory distress syndrome suffer decrements in physical function and health-related quality of life (HR-QoL) however it is unclear whether HR-QoL is disproportionately affected in those with H1N1 influenza. Objectives The objective was to compare the HR-QoL of patients with a diagnosis of H1N1 influenza who were mechanically ventilated, twelve months following ICU with healthy population data and ICU survivor data. Methods A prospective, observational, binational, multi-centre cohort study was conducted in eleven ICUs in Australia and New Zealand during June-September, 2009. Eligible participants were mechanically ventilated in the ICU with a confirmed diagnosis of H1N1 influenza. People were excluded if aged <18 years or could not speak English. Two validated HR-QoL questionnaires (Short Form-36 Version 2 (SF-36); the Assessment of Quality of Life (AQoL)) were administered one year following ICU. Measurements and main results Sixty-two patients (48 male) had median (IQR) age 42 (29 to 53) years, APACHE II score 18.0 (14 to 20); ventilation days 10.0 (4 to 23); ICU and hospital LOS 12.5 (7 - 27) and 20.0 (15 - 38) days respectively. Hospital mortality was 7 and 31 of the cohort received a tracheostomy. The mean (SD) health utility score at one year was 0.68 (0.30) compared to the healthy age-matched population (0.81 (0.23)). The mean (SD) SF-36 physical and mental component summary scores were within population normal ranges at 44.4 (12.3) and 45.5 (12.5) respectively. Conclusions Health-related quality of life of Australasian survivors of severe H1N1 influenza was comparable to the healthy population one year following ICU discharge. Consensus should be sought on standardization of follow-up time points and outcome measurement. Clinical trial registration The trial was registered with the Australian and New Zealand Clinical Trials Registry available at ACTRN12609001037291. Registered December 4th 2009.
Original languageEnglish
Pages (from-to)895 - 903
Number of pages9
JournalAnnals of the American Thoracic Society
Issue number6
Publication statusPublished - 2015

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