TY - JOUR
T1 - Health-related quality of life as a predictor of tuberculosis treatment outcomes in Iraq
AU - Dujaili, Juman Abdulelah
AU - Sulaiman, Syed Azhar Syed
AU - Hassali, Mohamed Azmi
AU - Awaisu, Ahmed
AU - Blebil, Ali Qais
AU - Bredle, Jason M.
N1 - Funding Information:
The authors would like to thank the investigators of the Thoracic and Respiratory Diseases Specialist Centre in Iraq for their help and support in the collection of the required data. We also greatly acknowledge the support provided by the FACIT measurement system and FACT-G developers for granting permission to use the FACT-G and for their input during the FACIT-TB development process. This research project was sponsored in part by a grant from Universiti Sains Malaysia, Research University Postgraduate Research Grant Scheme (USM-RU-PRGS; grant number 1001/PFARMASI/845040).
Publisher Copyright:
© 2014 The Authors.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - Objectives: To determine how tuberculosis (TB) treatment affects the health-related quality of life (HRQL) of patients with pulmonary TB and to identify the predictors of favourable TB treatment outcomes in Baghdad, Iraq. Methods: The Functional Assessment of Chronic Illness Therapy - Tuberculosis (FACIT-TB), a new TBspecific quality of life instrument derived from the internationally recognized FACIT measurement system for the assessment of HRQL, was administered. The mean total and subscale scores of the FACITTB at baseline, end of the intensive phase, and end of TB treatment were compared. Results: After the 2-month intensive phase, physical well-being, functional well-being, and the overall total scores were significantly increased (p < 0.01). Furthermore, at completion of TB treatment, there were significant improvements in the overall HRQL as indicated by the FACIT-TB total score and all subscales, except social and economic well-being and spiritual well-being. In a direct logistic regression model, only the FACIT-TB total score made a statistically significant contribution towards predicting the likelihood that a patient would have a favourable TB treatment outcome. Conclusions: Therapeutic intervention had a positive impact on patient HRQL. We conclude that FACITTB is a reliable tool to monitor HRQL during the course of TB treatment.
AB - Objectives: To determine how tuberculosis (TB) treatment affects the health-related quality of life (HRQL) of patients with pulmonary TB and to identify the predictors of favourable TB treatment outcomes in Baghdad, Iraq. Methods: The Functional Assessment of Chronic Illness Therapy - Tuberculosis (FACIT-TB), a new TBspecific quality of life instrument derived from the internationally recognized FACIT measurement system for the assessment of HRQL, was administered. The mean total and subscale scores of the FACITTB at baseline, end of the intensive phase, and end of TB treatment were compared. Results: After the 2-month intensive phase, physical well-being, functional well-being, and the overall total scores were significantly increased (p < 0.01). Furthermore, at completion of TB treatment, there were significant improvements in the overall HRQL as indicated by the FACIT-TB total score and all subscales, except social and economic well-being and spiritual well-being. In a direct logistic regression model, only the FACIT-TB total score made a statistically significant contribution towards predicting the likelihood that a patient would have a favourable TB treatment outcome. Conclusions: Therapeutic intervention had a positive impact on patient HRQL. We conclude that FACITTB is a reliable tool to monitor HRQL during the course of TB treatment.
KW - FACIT
KW - FACT-G
KW - HRQL
KW - Outcome
KW - Treatment
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=84930942619&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2014.12.004
DO - 10.1016/j.ijid.2014.12.004
M3 - Article
C2 - 25486011
AN - SCOPUS:84930942619
VL - 31
SP - 4
EP - 8
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
IS - 1
ER -