Health-related quality of life and health utility score of patients with gastric cancer: a multi-centre cross-sectional survey in China

Ruyi Xia, Hongmei Zeng, Qian Liu, Shuzheng Liu, Zhiyi Zhang, Yuqin Liu, Guizhou Guo, Guohui Song, Yigong Zhu, Xianghong Wu, Bingbing Song, Xianzhen Liao, Yanfang Chen, Wenqiang Wei, Gang Chen, Wanqing Chen, Guihua Zhuang

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Objective: To evaluate the health-related quality of life (HRQoL) and health state utility scores of gastric cancer patients in daily life at different clinical stages after treatment, and to explore influencing factors associated with HRQoL. Methods: Gastric cancer patients discharged from hospitals and healthy controls identified by screening were recruited. The three-level EQ-5D was employed to assess HRQoL and was scored using two Chinese-specific tariffs published in 2014 and 2018. Results: A total of 1,399 patients and 2,179 healthy controls were recruited. The likelihood of reporting problems in the five dimensions for patients was 4.0–23.8 times higher than controls. Based on the 2014/2018 tariff, the mean EQ-5D utility score was 0.321/0.163 lower than controls, and the mean utility scores of each patient subgroup were 0.077/0.039 (high-grade intraepithelial neoplasia/carcinoma in situ), 0.254/0.121 (Stage I), 0.249/0.123 (Stage II), 0.353/0.182 (Stage III) and 0.591/0.309 (Stage IV) lower than controls (all statistically significant). Age, occupation, duration of illness, other chronic disease status and therapeutic regimen had a significant impact upon different aspects of HRQoL in patients. Conclusions: Gastric cancer significantly impaired patients' HRQoL in daily life after treatment. More advanced cancer stages were associated with larger decrements on health state utility.

Original languageEnglish
Article numbere13283
Number of pages13
JournalEuropean Journal of Cancer Care
Issue number6
Publication statusPublished - Nov 2020


  • China
  • EQ-5D
  • gastric cancer
  • health state utility
  • health-related quality of life

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