Health of adults aged 22 to 35 years conceived by assisted reproductive technology

Jane Halliday, Sharon Lewis, Joanne Kennedy, David P. Burgner, Markus Juonala, Karin Hammarberg, David J. Amor, Lex W. Doyle, Richard Saffery, Sarath Ranganathan, Liam Welsh, Michael Cheung, John McBain, Stephen J.C. Hearps, Robert McLachlan

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Objective: To determine the health outcomes for adults aged 22–35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART. Design: Cohort study. Setting: Not applicable. Patient(s): Adult men and women aged 22–35 years who were conceived with and without use of ART. Intervention(s): Questionnaire and clinical review. Main Outcome Measure(s): Vascular structure (carotid artery intima-media thickness, pulse wave velocity), vascular function (blood pressure), metabolic markers (fasting blood glucose, insulin, and standard lipid profiles), anthropometric measurements, and respiratory function (spirometry). Result(s): The mean age of the 193 ART and 86 non-ART participants was 27.0 and 26.9 years, respectively. There were no substantial intragroup differences in demographics or vascular intermediate phenotypes, metabolic parameters, or anthropometric measures, before or after adjusting for perinatal factors and a quality of life measure with four domains. Diastolic blood pressure was lower in the ART men than the non-ART men (adjusted mean difference −4.4 mm Hg, 95% CI, −8.7 to −0.1). The ART group reported a higher prevalence of ever having asthma, (40.8% vs. 28.6%; odds ratio 1.7; 95% CI, 1.0–3.0), but expiratory flow rates were similar. Conclusion(s): This study of the health of 193 adults conceived via ART, the largest to date globally, found no evidence of increased vascular or cardiometabolic risk, or growth or respiratory problems in the ART group compared with a non-ART group from the same source population. Follow-up observation for reproductive and later-onset adverse health effects remains important.

Original languageEnglish
Pages (from-to)130-139
Number of pages10
JournalFertility and Sterility
Volume112
Issue number1
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Adults
  • ART
  • cardiovascular
  • cohort
  • respiratory

Cite this

Halliday, Jane ; Lewis, Sharon ; Kennedy, Joanne ; Burgner, David P. ; Juonala, Markus ; Hammarberg, Karin ; Amor, David J. ; Doyle, Lex W. ; Saffery, Richard ; Ranganathan, Sarath ; Welsh, Liam ; Cheung, Michael ; McBain, John ; Hearps, Stephen J.C. ; McLachlan, Robert. / Health of adults aged 22 to 35 years conceived by assisted reproductive technology. In: Fertility and Sterility. 2019 ; Vol. 112, No. 1. pp. 130-139.
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abstract = "Objective: To determine the health outcomes for adults aged 22–35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART. Design: Cohort study. Setting: Not applicable. Patient(s): Adult men and women aged 22–35 years who were conceived with and without use of ART. Intervention(s): Questionnaire and clinical review. Main Outcome Measure(s): Vascular structure (carotid artery intima-media thickness, pulse wave velocity), vascular function (blood pressure), metabolic markers (fasting blood glucose, insulin, and standard lipid profiles), anthropometric measurements, and respiratory function (spirometry). Result(s): The mean age of the 193 ART and 86 non-ART participants was 27.0 and 26.9 years, respectively. There were no substantial intragroup differences in demographics or vascular intermediate phenotypes, metabolic parameters, or anthropometric measures, before or after adjusting for perinatal factors and a quality of life measure with four domains. Diastolic blood pressure was lower in the ART men than the non-ART men (adjusted mean difference −4.4 mm Hg, 95{\%} CI, −8.7 to −0.1). The ART group reported a higher prevalence of ever having asthma, (40.8{\%} vs. 28.6{\%}; odds ratio 1.7; 95{\%} CI, 1.0–3.0), but expiratory flow rates were similar. Conclusion(s): This study of the health of 193 adults conceived via ART, the largest to date globally, found no evidence of increased vascular or cardiometabolic risk, or growth or respiratory problems in the ART group compared with a non-ART group from the same source population. Follow-up observation for reproductive and later-onset adverse health effects remains important.",
keywords = "Adults, ART, cardiovascular, cohort, respiratory",
author = "Jane Halliday and Sharon Lewis and Joanne Kennedy and Burgner, {David P.} and Markus Juonala and Karin Hammarberg and Amor, {David J.} and Doyle, {Lex W.} and Richard Saffery and Sarath Ranganathan and Liam Welsh and Michael Cheung and John McBain and Hearps, {Stephen J.C.} and Robert McLachlan",
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Halliday, J, Lewis, S, Kennedy, J, Burgner, DP, Juonala, M, Hammarberg, K, Amor, DJ, Doyle, LW, Saffery, R, Ranganathan, S, Welsh, L, Cheung, M, McBain, J, Hearps, SJC & McLachlan, R 2019, 'Health of adults aged 22 to 35 years conceived by assisted reproductive technology', Fertility and Sterility, vol. 112, no. 1, pp. 130-139. https://doi.org/10.1016/j.fertnstert.2019.03.001

Health of adults aged 22 to 35 years conceived by assisted reproductive technology. / Halliday, Jane; Lewis, Sharon; Kennedy, Joanne; Burgner, David P.; Juonala, Markus; Hammarberg, Karin; Amor, David J.; Doyle, Lex W.; Saffery, Richard; Ranganathan, Sarath; Welsh, Liam; Cheung, Michael; McBain, John; Hearps, Stephen J.C.; McLachlan, Robert.

In: Fertility and Sterility, Vol. 112, No. 1, 01.07.2019, p. 130-139.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Health of adults aged 22 to 35 years conceived by assisted reproductive technology

AU - Halliday, Jane

AU - Lewis, Sharon

AU - Kennedy, Joanne

AU - Burgner, David P.

AU - Juonala, Markus

AU - Hammarberg, Karin

AU - Amor, David J.

AU - Doyle, Lex W.

AU - Saffery, Richard

AU - Ranganathan, Sarath

AU - Welsh, Liam

AU - Cheung, Michael

AU - McBain, John

AU - Hearps, Stephen J.C.

AU - McLachlan, Robert

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective: To determine the health outcomes for adults aged 22–35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART. Design: Cohort study. Setting: Not applicable. Patient(s): Adult men and women aged 22–35 years who were conceived with and without use of ART. Intervention(s): Questionnaire and clinical review. Main Outcome Measure(s): Vascular structure (carotid artery intima-media thickness, pulse wave velocity), vascular function (blood pressure), metabolic markers (fasting blood glucose, insulin, and standard lipid profiles), anthropometric measurements, and respiratory function (spirometry). Result(s): The mean age of the 193 ART and 86 non-ART participants was 27.0 and 26.9 years, respectively. There were no substantial intragroup differences in demographics or vascular intermediate phenotypes, metabolic parameters, or anthropometric measures, before or after adjusting for perinatal factors and a quality of life measure with four domains. Diastolic blood pressure was lower in the ART men than the non-ART men (adjusted mean difference −4.4 mm Hg, 95% CI, −8.7 to −0.1). The ART group reported a higher prevalence of ever having asthma, (40.8% vs. 28.6%; odds ratio 1.7; 95% CI, 1.0–3.0), but expiratory flow rates were similar. Conclusion(s): This study of the health of 193 adults conceived via ART, the largest to date globally, found no evidence of increased vascular or cardiometabolic risk, or growth or respiratory problems in the ART group compared with a non-ART group from the same source population. Follow-up observation for reproductive and later-onset adverse health effects remains important.

AB - Objective: To determine the health outcomes for adults aged 22–35 years old who were conceived via assisted reproduction technology (ART) compared with adults of the same age conceived without use of ART. Design: Cohort study. Setting: Not applicable. Patient(s): Adult men and women aged 22–35 years who were conceived with and without use of ART. Intervention(s): Questionnaire and clinical review. Main Outcome Measure(s): Vascular structure (carotid artery intima-media thickness, pulse wave velocity), vascular function (blood pressure), metabolic markers (fasting blood glucose, insulin, and standard lipid profiles), anthropometric measurements, and respiratory function (spirometry). Result(s): The mean age of the 193 ART and 86 non-ART participants was 27.0 and 26.9 years, respectively. There were no substantial intragroup differences in demographics or vascular intermediate phenotypes, metabolic parameters, or anthropometric measures, before or after adjusting for perinatal factors and a quality of life measure with four domains. Diastolic blood pressure was lower in the ART men than the non-ART men (adjusted mean difference −4.4 mm Hg, 95% CI, −8.7 to −0.1). The ART group reported a higher prevalence of ever having asthma, (40.8% vs. 28.6%; odds ratio 1.7; 95% CI, 1.0–3.0), but expiratory flow rates were similar. Conclusion(s): This study of the health of 193 adults conceived via ART, the largest to date globally, found no evidence of increased vascular or cardiometabolic risk, or growth or respiratory problems in the ART group compared with a non-ART group from the same source population. Follow-up observation for reproductive and later-onset adverse health effects remains important.

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