HDL and cardiovascular disease

Stephen J. Nicholls, Adam J. Nelson

Research output: Contribution to journalReview ArticleOtherpeer-review

14 Citations (Scopus)


High-density lipoprotein (HDL) has received increasing interest due to observations of an inverse relationship between its systemic levels and cardiovascular risk and targeted interventions in animal models that have had favourable effects on atherosclerotic plaque. In addition to its pivotal role in reverse cholesterol transport, HDL has been reported to possess a range of functional properties, which may exert a protective influence on inflammation, oxidation, angiogenesis and glucose homeostasis. This has led to the development of a range of HDL targeted therapeutics, which have undergone evaluation in clinical trials. The current state of HDL in cardiovascular prevention will be reviewed.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
Issue number2
Publication statusPublished - 1 Feb 2019


  • atherosclerosis
  • cardiovascular risk
  • clinical trials
  • HDL
  • lipids

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