HDAC inhibitors in HIV

Fiona Wightman, Paula Clarisa Ellenberg, Melissa Churchill, Sharon R Lewin

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

Abstract

Combination antiretroviral therapy (cART) has led to a very substantial reduction in morbidity and mortality in HIV-infected patients; however, cART alone is unable to cure HIV and therapy is lifelong. Therefore, a new strategy to cure HIV is urgently needed. There is now a concerted effort from scientists, clinicians and funding agencies to identify ways to achieve either a functional cure (long-term control of HIV in the absence of cART) or a sterilizing cure (elimination of all HIV-infected cells). Multiple strategies aiming at achieving a cure for HIV are currently being investigated, including both pharmacotherapy and gene therapy. In this review, we will review the rationale as well as in vitro and clinical trial data that support the role of histone deacetylase inhibitors as one approach to cure HIV.
Original languageEnglish
Pages (from-to)47 - 54
Number of pages8
JournalImmunology and Cell Biology
Volume90
Issue number1
DOIs
Publication statusPublished - 2012

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