Haven’t we been doing multidimensional GC analysis forever? So, what is new?

Philip J Marriott, Yong Foo Wong

Research output: Contribution to journalComment / DebateOther

Abstract

Multidimensional analysis (MDA) certainly has been done for a long time! Many people are, to a lesser or greater degree,experienced in MDA. By MDA, we mean hyphenated chemical analysis combining two distinct techniques that themselves are bona fide analysis methods. The most recognizable MDA technique is gas chromatography–mass spectrometry (GC –MS)—combining dimensions of GC, which generates a sequence of time-resolved components and potentially constitutes molecular speciation, with a mass spectrum that provides some measure of molecular specificity by virtue of the mass fragmentation pattern of a molecule. By all accounts, GC–MS operates reliably, reproducibly, and sensitively for components detected by MS, for a sample that is resolved into chemical components by GC . Without further information, GC lacks molecular specificity, sinc eit just gives the recognized peak response to each compound in a sample. If we can assign each response to a specific compound,then GC provides reliable molecular information. Thus, GC–MS is used as both a screening and target analysis method — we get a snapshot of the total sample or we can analyze a subset of compounds.
Original languageEnglish
Pages (from-to)21-22
Number of pages2
JournalLC-GC North America
Volume35
Issue number8
Publication statusPublished - 2017

Cite this

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title = "Haven’t we been doing multidimensional GC analysis forever? So, what is new?",
abstract = "Multidimensional analysis (MDA) certainly has been done for a long time! Many people are, to a lesser or greater degree,experienced in MDA. By MDA, we mean hyphenated chemical analysis combining two distinct techniques that themselves are bona fide analysis methods. The most recognizable MDA technique is gas chromatography–mass spectrometry (GC –MS)—combining dimensions of GC, which generates a sequence of time-resolved components and potentially constitutes molecular speciation, with a mass spectrum that provides some measure of molecular specificity by virtue of the mass fragmentation pattern of a molecule. By all accounts, GC–MS operates reliably, reproducibly, and sensitively for components detected by MS, for a sample that is resolved into chemical components by GC . Without further information, GC lacks molecular specificity, sinc eit just gives the recognized peak response to each compound in a sample. If we can assign each response to a specific compound,then GC provides reliable molecular information. Thus, GC–MS is used as both a screening and target analysis method — we get a snapshot of the total sample or we can analyze a subset of compounds.",
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Haven’t we been doing multidimensional GC analysis forever? So, what is new? / Marriott, Philip J; Wong, Yong Foo.

In: LC-GC North America, Vol. 35, No. 8, 2017, p. 21-22.

Research output: Contribution to journalComment / DebateOther

TY - JOUR

T1 - Haven’t we been doing multidimensional GC analysis forever? So, what is new?

AU - Marriott, Philip J

AU - Wong, Yong Foo

PY - 2017

Y1 - 2017

N2 - Multidimensional analysis (MDA) certainly has been done for a long time! Many people are, to a lesser or greater degree,experienced in MDA. By MDA, we mean hyphenated chemical analysis combining two distinct techniques that themselves are bona fide analysis methods. The most recognizable MDA technique is gas chromatography–mass spectrometry (GC –MS)—combining dimensions of GC, which generates a sequence of time-resolved components and potentially constitutes molecular speciation, with a mass spectrum that provides some measure of molecular specificity by virtue of the mass fragmentation pattern of a molecule. By all accounts, GC–MS operates reliably, reproducibly, and sensitively for components detected by MS, for a sample that is resolved into chemical components by GC . Without further information, GC lacks molecular specificity, sinc eit just gives the recognized peak response to each compound in a sample. If we can assign each response to a specific compound,then GC provides reliable molecular information. Thus, GC–MS is used as both a screening and target analysis method — we get a snapshot of the total sample or we can analyze a subset of compounds.

AB - Multidimensional analysis (MDA) certainly has been done for a long time! Many people are, to a lesser or greater degree,experienced in MDA. By MDA, we mean hyphenated chemical analysis combining two distinct techniques that themselves are bona fide analysis methods. The most recognizable MDA technique is gas chromatography–mass spectrometry (GC –MS)—combining dimensions of GC, which generates a sequence of time-resolved components and potentially constitutes molecular speciation, with a mass spectrum that provides some measure of molecular specificity by virtue of the mass fragmentation pattern of a molecule. By all accounts, GC–MS operates reliably, reproducibly, and sensitively for components detected by MS, for a sample that is resolved into chemical components by GC . Without further information, GC lacks molecular specificity, sinc eit just gives the recognized peak response to each compound in a sample. If we can assign each response to a specific compound,then GC provides reliable molecular information. Thus, GC–MS is used as both a screening and target analysis method — we get a snapshot of the total sample or we can analyze a subset of compounds.

M3 - Comment / Debate

VL - 35

SP - 21

EP - 22

JO - LC-GC North America

JF - LC-GC North America

SN - 1527-5949

IS - 8

ER -