Harnessing adaptive natural killer cells in cancer immunotherapy

Lisa L. Liu, Aline Pfefferle, Vincent Oei Yi Sheng, Andreas T. Björklund, Vivien Béziat, Jodie P. Goodridge, Karl Johan Malmberg

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Natural killer (NK) cells are innate lymphocytes with a refined ability to recognize transformed cells through a broad array of activating receptors in combination with stochastically expressed inhibitory receptors that recognize MHC-class I. Recent advances in NK cell biology have revealed a high degree of functional plasticity that can be attributed to dynamic cell-to-cell interactions in concert with transcriptional and epigenetic reprogramming. Here, we discuss how new insights into the adaptive behavior of NK cells pave the way for next generation cell therapy based on guided differentiation and selective expansion of particularly cytotoxic NK cell subsets.

Original languageEnglish
Pages (from-to)1904-1917
Number of pages14
JournalMolecular Oncology
Volume9
Issue number10
DOIs
Publication statusPublished - Dec 2015
Externally publishedYes

Keywords

  • Adaptive
  • Immunotherapy
  • Killer cell immunoglobulin-like receptors
  • NK cells
  • NKG2C

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