Haemostasis and innate immunity – a complementary relationship: A review of the intricate relationship between coagulation and complement pathways

Charithani B. Keragala, Dominik F. Draxler, Zoe K. McQuilten, Robert L. Medcalf

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Coagulation and innate immunity are linked evolutionary processes that orchestrate the host defence against invading pathogens and injury. The complement system is integral to innate immunity and shares numerous interactions with components of the haemostatic pathway, helping to maintain physiological equilibrium. The term ‘immunothrombosis’ was introduced in 2013 to embrace this process, and has become an area of much recent interest. What is less apparent in the literature however is an appreciation of the clinical manifestations of the coagulation-complement interaction and the consequences of dysregulation of either system, as seen in many inflammatory and thrombotic disease states, such as sepsis, trauma, atherosclerosis, antiphospholipid syndrome (APS), paroxysmal nocturnal haemoglobinuria (PNH) and some thrombotic microangiopathies to name a few. The growing appreciation of this immunothrombotic phenomenon will foster the drive for novel therapies in these disease states, including anticoagulants as immunomodulators and targeted molecular therapies.

Original languageEnglish
Pages (from-to)782-798
Number of pages17
JournalBritish Journal of Haematology
Volume180
Issue number6
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • coagulation
  • complement
  • haemostasis
  • immunothrombosis
  • innate immunity

Cite this

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abstract = "Coagulation and innate immunity are linked evolutionary processes that orchestrate the host defence against invading pathogens and injury. The complement system is integral to innate immunity and shares numerous interactions with components of the haemostatic pathway, helping to maintain physiological equilibrium. The term ‘immunothrombosis’ was introduced in 2013 to embrace this process, and has become an area of much recent interest. What is less apparent in the literature however is an appreciation of the clinical manifestations of the coagulation-complement interaction and the consequences of dysregulation of either system, as seen in many inflammatory and thrombotic disease states, such as sepsis, trauma, atherosclerosis, antiphospholipid syndrome (APS), paroxysmal nocturnal haemoglobinuria (PNH) and some thrombotic microangiopathies to name a few. The growing appreciation of this immunothrombotic phenomenon will foster the drive for novel therapies in these disease states, including anticoagulants as immunomodulators and targeted molecular therapies.",
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Haemostasis and innate immunity – a complementary relationship : A review of the intricate relationship between coagulation and complement pathways. / Keragala, Charithani B.; Draxler, Dominik F.; McQuilten, Zoe K.; Medcalf, Robert L.

In: British Journal of Haematology, Vol. 180, No. 6, 01.03.2018, p. 782-798.

Research output: Contribution to journalReview ArticleResearchpeer-review

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