TY - JOUR
T1 - Haemorrhage-induced production of Fos in neurons of the lamina terminalis
T2 - role of endogenous angiotensin II
AU - Badoer, Emilio
AU - Oldfield, Brian J.
AU - McKinley, Michael J.
PY - 1993/9/3
Y1 - 1993/9/3
N2 - Hypotensive haemorrhage increased the production of Fos, a marker of cell activation, in cells of the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) as well as in the supraoptic (SON) and paraventricular (PVN) nuclei in conscious rats. Pretreatment with captopril (100 mg/kg i.p.) inhibited the production of Fos in cells of the SFO and OVLT but did not reduce the concentration of Fos-positive cell nuclei in the PVN and SON. The results suggest that the production of Fos in the SFO and OVLT induced by the haemorrhage is probably due to elevated levels of circulating angiotensin II.
AB - Hypotensive haemorrhage increased the production of Fos, a marker of cell activation, in cells of the subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) as well as in the supraoptic (SON) and paraventricular (PVN) nuclei in conscious rats. Pretreatment with captopril (100 mg/kg i.p.) inhibited the production of Fos in cells of the SFO and OVLT but did not reduce the concentration of Fos-positive cell nuclei in the PVN and SON. The results suggest that the production of Fos in the SFO and OVLT induced by the haemorrhage is probably due to elevated levels of circulating angiotensin II.
KW - Angiotensin II
KW - Fos immunoreactivity
KW - Hemorrhage
KW - Lamina terminalis
UR - http://www.scopus.com/inward/record.url?scp=0027306842&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90821-2
DO - 10.1016/0304-3940(93)90821-2
M3 - Article
C2 - 8264959
AN - SCOPUS:0027306842
VL - 159
SP - 151
EP - 154
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1-2
ER -