Haemodynamic effects and uptake on enflurane in patients undergoing cardiac surgery: Good versus poor myocardial function

P. S. Myles, C. Millar

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We measured haemodynamic effects and uptake of enflurane in patients undergoing cardiac surgery utilizing a standard anaesthetic technique of fentanyl 15 mcg/kg nitrous oxide 50%/enflurane 1%. We divided 22 patients preoperatively into two groups according to standard criteria: good and poor myocardial function. Regression lines could be drawn illustrating the relationship of cardiac output and uptake (at 1 minute: r = -0.56, P < 0.01; at 5 minutes: r = -0.43, P < 0.05; at 30 minutes.: r = -0.31, P = 0.08). Although patients with poor myocardial function had decreased uptake of enflurance (approximately 10-20%), this did not reach statistical significance. Fentanyl/nitrous oxide/enflurane anaesthesia provided stable haemodynamics, even in patients with poor myocardial functicn. Both groups had a shunt fraction of approximately 10% and an arterial: end-tidal carbon dioxide difference of approximately 3-4 mmHg.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalAnaesthesia and intensive care
Volume20
Issue number1
Publication statusPublished - 1992
Externally publishedYes

Cite this

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abstract = "We measured haemodynamic effects and uptake of enflurane in patients undergoing cardiac surgery utilizing a standard anaesthetic technique of fentanyl 15 mcg/kg nitrous oxide 50{\%}/enflurane 1{\%}. We divided 22 patients preoperatively into two groups according to standard criteria: good and poor myocardial function. Regression lines could be drawn illustrating the relationship of cardiac output and uptake (at 1 minute: r = -0.56, P < 0.01; at 5 minutes: r = -0.43, P < 0.05; at 30 minutes.: r = -0.31, P = 0.08). Although patients with poor myocardial function had decreased uptake of enflurance (approximately 10-20{\%}), this did not reach statistical significance. Fentanyl/nitrous oxide/enflurane anaesthesia provided stable haemodynamics, even in patients with poor myocardial functicn. Both groups had a shunt fraction of approximately 10{\%} and an arterial: end-tidal carbon dioxide difference of approximately 3-4 mmHg.",
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Haemodynamic effects and uptake on enflurane in patients undergoing cardiac surgery : Good versus poor myocardial function. / Myles, P. S.; Millar, C.

In: Anaesthesia and intensive care, Vol. 20, No. 1, 1992, p. 21-27.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Haemodynamic effects and uptake on enflurane in patients undergoing cardiac surgery

T2 - Good versus poor myocardial function

AU - Myles, P. S.

AU - Millar, C.

PY - 1992

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AB - We measured haemodynamic effects and uptake of enflurane in patients undergoing cardiac surgery utilizing a standard anaesthetic technique of fentanyl 15 mcg/kg nitrous oxide 50%/enflurane 1%. We divided 22 patients preoperatively into two groups according to standard criteria: good and poor myocardial function. Regression lines could be drawn illustrating the relationship of cardiac output and uptake (at 1 minute: r = -0.56, P < 0.01; at 5 minutes: r = -0.43, P < 0.05; at 30 minutes.: r = -0.31, P = 0.08). Although patients with poor myocardial function had decreased uptake of enflurance (approximately 10-20%), this did not reach statistical significance. Fentanyl/nitrous oxide/enflurane anaesthesia provided stable haemodynamics, even in patients with poor myocardial functicn. Both groups had a shunt fraction of approximately 10% and an arterial: end-tidal carbon dioxide difference of approximately 3-4 mmHg.

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