H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

M. S. Schinkelshoek; R. Fronczek; E. M.C. Kooy-Winkelaar; J. Petersen; H. H. Reid; A. van der Heide; J. W. Drijfhout; J. Rossjohn; G. J. Lammers; F. Koning

doi:10.1016/j.jneuroim.2019.04.009

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

M. S. Schinkelshoek, R. Fronczek, E. M.C. Kooy-Winkelaar, J. Petersen, H. H. Reid, A. van der Heide, J. W. Drijfhout, J. Rossjohn, G. J. Lammers, F. Koning

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.

Original language	English
Pages (from-to)	167-175
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	332
DOIs	https://doi.org/10.1016/j.jneuroim.2019.04.009
Publication status	Published - 15 Jul 2019

Keywords

Cross-reactivity
H1N1
Hypocretin
Narcolepsy
T cells

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10.1016/j.jneuroim.2019.04.009

272752730-oaFinal published version, 6.85 MB

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Schinkelshoek, M. S., Fronczek, R., Kooy-Winkelaar, E. M. C., Petersen, J., Reid, H. H., van der Heide, A., Drijfhout, J. W., Rossjohn, J., Lammers, G. J., & Koning, F. (2019). H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. Journal of Neuroimmunology, 332, 167-175. https://doi.org/10.1016/j.jneuroim.2019.04.009

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title = "H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls",

abstract = "Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.",

keywords = "Cross-reactivity, H1N1, Hypocretin, Narcolepsy, T cells",

author = "Schinkelshoek, {M. S.} and R. Fronczek and Kooy-Winkelaar, {E. M.C.} and J. Petersen and Reid, {H. H.} and {van der Heide}, A. and Drijfhout, {J. W.} and J. Rossjohn and Lammers, {G. J.} and F. Koning",

year = "2019",

month = jul,

day = "15",

doi = "10.1016/j.jneuroim.2019.04.009",

language = "English",

volume = "332",

pages = "167--175",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier BV",

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Schinkelshoek, MS, Fronczek, R, Kooy-Winkelaar, EMC, Petersen, J, Reid, HH, van der Heide, A, Drijfhout, JW, Rossjohn, J, Lammers, GJ & Koning, F 2019, 'H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls', Journal of Neuroimmunology, vol. 332, pp. 167-175. https://doi.org/10.1016/j.jneuroim.2019.04.009

TY - JOUR

T1 - H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

AU - Schinkelshoek, M. S.

AU - Fronczek, R.

AU - Kooy-Winkelaar, E. M.C.

AU - Petersen, J.

AU - Reid, H. H.

AU - van der Heide, A.

AU - Drijfhout, J. W.

AU - Rossjohn, J.

AU - Lammers, G. J.

AU - Koning, F.

PY - 2019/7/15

Y1 - 2019/7/15

N2 - Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.

AB - Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.

KW - Cross-reactivity

KW - H1N1

KW - Hypocretin

KW - Narcolepsy

KW - T cells

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DO - 10.1016/j.jneuroim.2019.04.009

M3 - Article

AN - SCOPUS:85064877326

SN - 0165-5728

VL - 332

SP - 167

EP - 175

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

Abstract

Keywords

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ARC Centre of Excellence in Advanced Molecular Imaging

Australian Synchrotron

Cite this

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

Abstract

Keywords

Access to Document

Other files and links

Projects

ARC Centre of Excellence in Advanced Molecular Imaging

Equipment

Australian Synchrotron

Cite this