H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

M. S. Schinkelshoek, R. Fronczek, E. M.C. Kooy-Winkelaar, J. Petersen, H. H. Reid, A. van der Heide, J. W. Drijfhout, J. Rossjohn, G. J. Lammers, F. Koning

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.

Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalJournal of Neuroimmunology
Volume332
DOIs
Publication statusPublished - 15 Jul 2019

Keywords

  • Cross-reactivity
  • H1N1
  • Hypocretin
  • Narcolepsy
  • T cells

Cite this

Schinkelshoek, M. S. ; Fronczek, R. ; Kooy-Winkelaar, E. M.C. ; Petersen, J. ; Reid, H. H. ; van der Heide, A. ; Drijfhout, J. W. ; Rossjohn, J. ; Lammers, G. J. ; Koning, F. / H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. In: Journal of Neuroimmunology. 2019 ; Vol. 332. pp. 167-175.
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title = "H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls",
abstract = "Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4{\%} of patients and 15.8{\%} of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.",
keywords = "Cross-reactivity, H1N1, Hypocretin, Narcolepsy, T cells",
author = "Schinkelshoek, {M. S.} and R. Fronczek and Kooy-Winkelaar, {E. M.C.} and J. Petersen and Reid, {H. H.} and {van der Heide}, A. and Drijfhout, {J. W.} and J. Rossjohn and Lammers, {G. J.} and F. Koning",
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H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. / Schinkelshoek, M. S.; Fronczek, R.; Kooy-Winkelaar, E. M.C.; Petersen, J.; Reid, H. H.; van der Heide, A.; Drijfhout, J. W.; Rossjohn, J.; Lammers, G. J.; Koning, F.

In: Journal of Neuroimmunology, Vol. 332, 15.07.2019, p. 167-175.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Schinkelshoek, M. S.

AU - Fronczek, R.

AU - Kooy-Winkelaar, E. M.C.

AU - Petersen, J.

AU - Reid, H. H.

AU - van der Heide, A.

AU - Drijfhout, J. W.

AU - Rossjohn, J.

AU - Lammers, G. J.

AU - Koning, F.

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