Histamine H 3 receptors are presynaptic autoreceptors on histamine-containing neurons, activation of which leads to inhibition of the synthesis and release of histamine. They are also present on non-histamine containing neurons as "hetero-receptors", where they regulate other neurotransmitters such as serotonin, adrenaline and dopamine. The human histamine H 3 receptor has been described to display constitutive activity in heterologous expression systems, in the absence of agonist stimulation.
|Title of host publication
|Subtitle of host publication
|The Comprehensive Pharmacology Reference
|Number of pages
|Published - 2011