H-3 histamine receptor

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Abstract

Histamine H 3 receptors are presynaptic autoreceptors on histamine-containing neurons, activation of which leads to inhibition of the synthesis and release of histamine. They are also present on non-histamine containing neurons as "hetero-receptors", where they regulate other neurotransmitters such as serotonin, adrenaline and dopamine. The human histamine H 3 receptor has been described to display constitutive activity in heterologous expression systems, in the absence of agonist stimulation.

Original languageEnglish
Title of host publicationxPharm
Subtitle of host publicationThe Comprehensive Pharmacology Reference
PublisherAcademic Press
Pages1-6
Number of pages6
ISBN (Print)9780080552323
DOIs
Publication statusPublished - 2011
Externally publishedYes

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