Abstract
Histamine H 3 receptors are presynaptic autoreceptors on histamine-containing neurons, activation of which leads to inhibition of the synthesis and release of histamine. They are also present on non-histamine containing neurons as "hetero-receptors", where they regulate other neurotransmitters such as serotonin, adrenaline and dopamine. The human histamine H 3 receptor has been described to display constitutive activity in heterologous expression systems, in the absence of agonist stimulation.
Original language | English |
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Title of host publication | xPharm |
Subtitle of host publication | The Comprehensive Pharmacology Reference |
Publisher | Academic Press |
Pages | 1-6 |
Number of pages | 6 |
ISBN (Print) | 9780080552323 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |