The histamine H 2 receptor gene has been cloned from human, rat, mouse, dog and guinea pig. The receptor is present in gastric parietal cells, vascular smooth muscle and neutrophils as well as in the central nervous system. H 2 receptor antagonists have been used for many years clinically for the treatment of peptic ulcers in the gastrointestinal tract and are among the most widely prescribed drugs across the western world.
|Title of host publication||xPharm|
|Subtitle of host publication||The Comprehensive Pharmacology Reference|
|Number of pages||6|
|Publication status||Published - 2011|