H-1 histamine receptor

Kim Powell

doi:10.1016/B978-008055232-3.60118-7

H-1 histamine receptor

Kim Powell

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

Abstract

Histamine H ₁ receptors are expressed widely in the body, in particular in tissues such as smooth muscle, endothelial cells, adrenal medulla, heart, and central nervous system. Histamine is a major mediator in allergic reactions and the histamine H ₁ receptor is responsible for many of the symptoms of allergic reactions such as rhinorrhoea, contraction of bronchial and gastrointestinal smooth muscle and many forms of itch. H ₁ receptor antagonists are used extensively for the treatment of allergic disorders to the extent that " anti-histamines" would be universally recognized as a treatment for hayfever, for example, but not for asthma.

Original language	English
Title of host publication	xPharm
Subtitle of host publication	The Comprehensive Pharmacology Reference
Publisher	Academic Press
Pages	1-6
Number of pages	6
ISBN (Print)	9780080552323
DOIs	https://doi.org/10.1016/B978-008055232-3.60118-7
Publication status	Published - 2011
Externally published	Yes

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10.1016/B978-008055232-3.60118-7

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AB - Histamine H 1 receptors are expressed widely in the body, in particular in tissues such as smooth muscle, endothelial cells, adrenal medulla, heart, and central nervous system. Histamine is a major mediator in allergic reactions and the histamine H 1 receptor is responsible for many of the symptoms of allergic reactions such as rhinorrhoea, contraction of bronchial and gastrointestinal smooth muscle and many forms of itch. H 1 receptor antagonists are used extensively for the treatment of allergic disorders to the extent that " anti-histamines" would be universally recognized as a treatment for hayfever, for example, but not for asthma.

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H-1 histamine receptor

Abstract

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