H-1 histamine receptor

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Histamine H 1 receptors are expressed widely in the body, in particular in tissues such as smooth muscle, endothelial cells, adrenal medulla, heart, and central nervous system. Histamine is a major mediator in allergic reactions and the histamine H 1 receptor is responsible for many of the symptoms of allergic reactions such as rhinorrhoea, contraction of bronchial and gastrointestinal smooth muscle and many forms of itch. H 1 receptor antagonists are used extensively for the treatment of allergic disorders to the extent that " anti-histamines" would be universally recognized as a treatment for hayfever, for example, but not for asthma.

Original languageEnglish
Title of host publicationxPharm
Subtitle of host publicationThe Comprehensive Pharmacology Reference
PublisherAcademic Press
Number of pages6
ISBN (Print)9780080552323
Publication statusPublished - 2011
Externally publishedYes

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