Histamine H 1 receptors are expressed widely in the body, in particular in tissues such as smooth muscle, endothelial cells, adrenal medulla, heart, and central nervous system. Histamine is a major mediator in allergic reactions and the histamine H 1 receptor is responsible for many of the symptoms of allergic reactions such as rhinorrhoea, contraction of bronchial and gastrointestinal smooth muscle and many forms of itch. H 1 receptor antagonists are used extensively for the treatment of allergic disorders to the extent that " anti-histamines" would be universally recognized as a treatment for hayfever, for example, but not for asthma.
|Title of host publication||xPharm|
|Subtitle of host publication||The Comprehensive Pharmacology Reference|
|Number of pages||6|
|Publication status||Published - 2011|