Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

Dominique Gatto, Didrik Paus, Antony Basten, Charles Reay Mackay, Robert Brink

Research output: Contribution to journalArticleResearchpeer-review

183 Citations (Scopus)

Abstract

Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartments have not been fully elucidated. Here, we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses. Conversely, downregulation of EBI2 enabled B cells to access the center of follicles and promoted efficient GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.
Original languageEnglish
Pages (from-to)259 - 269
Number of pages11
JournalImmunity
Volume31
Issue number2
Publication statusPublished - 2009
Externally publishedYes

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