Growth of osteoblasts on lithographically modified surfaces

Sergey Gorelick, Paavo Rahkila, A. Sagari, Timo Sajavaara, Sulin Cheng, Lennart B. Karlsson, Jeroen A. van Kan, Harry J. Whitlow

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9 Citations (Scopus)

Abstract

Here we report about preliminary investigations on developing substrates for culturing osteoblasts, the cells responsible for production of mineralised bone, by lithographically modifying the surfaces of several materials. The proton beam writing system at the National University of Singapore was used to fabricate high aspect ratio structures in PMMA, while two-dimensional low aspect ratio structures were fabricated using conventional electron beam lithography (EBL) and UV lithography (UVL) in SU-8. It was found that oxygen plasma treatment of structured SU-8 surfaces changed the surface layer and significantly improved cell attachment and proliferation. Cells grown on patterned thick PMMA exhibit a remarkable geometry-dependent behaviour.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume260
Issue number1
DOIs
Publication statusPublished - 1 Jul 2007
Externally publishedYes

Keywords

  • Bone
  • Cell growth
  • Ion-sputtering
  • Osteoblast
  • PMMA
  • Proton beam writing
  • SU-8
  • Surface treatment

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