Growth hormone deficiency is frequent after recent stroke

Thomas Lillicrap, Carlos Garcia-Esperon, Frederick Rohan Walker, Lin Kooi Ong, Michael Nilsson, Neil Spratt, Christopher R. Levi, Mark Parsons, Jörgen Isgaard, Andrew Bivard

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6 Citations (Scopus)


Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke. Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset. Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7-16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges. Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.

Original languageEnglish
Article number713
Number of pages4
JournalFrontiers in Neurology
Publication statusPublished - 6 Sep 2018
Externally publishedYes


  • Cognition
  • Growth hormone
  • Ischemic stroke
  • Neuro recovery
  • Rehabilitation

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