Growth-blocking peptides as nutrition-sensitive signals for insulin secretion and body size regulation

Takashi Koyama, Christen K Mirth

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Abstract

In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling. Reducing the expression of GBP1 and GBP2 (GBPs) specifically in the fat body results in smaller body size due to reduced growth rate. In addition, we found that GBPs stimulate ILP secretion from the insulin-producing cells, either directly or indirectly, thereby increasing insulin and insulin-like growth factor signaling activity throughout the body. Our findings fill an important gap in our understanding of how the fat body transmits nutritional information to the insulin producing cells to control body size.
Original languageEnglish
Article numbere1002392
Pages (from-to)1-23
Number of pages23
JournalPLoS Biology
Volume14
Issue number2
DOIs
Publication statusPublished - 2016

Cite this

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Growth-blocking peptides as nutrition-sensitive signals for insulin secretion and body size regulation. / Koyama, Takashi; Mirth, Christen K.

In: PLoS Biology, Vol. 14, No. 2, e1002392, 2016, p. 1-23.

Research output: Contribution to journalArticleResearchpeer-review

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