Growing muscle has different sarcolemmal properties from adult muscle: A proposal with scientific and clinical implications: Reasons to reassess skeletal muscle molecular dynamics, cellular responses and suitability of experimental models of muscle disorders

Miranda D. Grounds, Thea Shavlakadze

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

We hypothesise that the sarcolemma of an actively growing myofibre has different properties to the sarcolemma of a mature adult myofibre. Such fundamentally different properties have clinical consequences for the onset, and potential therapeutic targets, of various skeletal muscle diseases that first manifest either during childhood (e.g. Duchenne muscular dystrophy, DMD) or after cessation of the main growth phase (e.g. dysferlinopathies). These characteristics are also relevant to the selection of both tissue culture and in vivo models employed to study such myopathies and the molecular regulation of adult myofibres. During growth, multinucleated myofibres increase enormously in size and volume with dramatic increases in length (up to ~600mm). This is in striking contrast with most mononucleated cells such as fibroblasts, that remain at a relatively small size (~10-20μm diameter). The consequences of a dynamic, expanding sarcolemma during growth, compared with that of an adult myofibre of a fixed length, are discussed with respect to various aspects of muscle biology. 

Original languageEnglish
Pages (from-to)458-468
Number of pages11
JournalBioEssays
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

Keywords

  • Growth
  • Muscular dystrophies
  • Myofibre elongation
  • Sarcolemma properties
  • Skeletal muscle

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