Gross morphological brain changes with chronic, heavy cannabis use

Valentina Lorenzetti, Nadia Solowij, Sarah Whittle, Alex Fornito, Dan I. Lubman, Christos Pantelis, Murat Yucel

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55 Citations (Scopus)


We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe
Original languageEnglish
Pages (from-to)77-78
Number of pages2
JournalBritish Journal of Psychiatry
Issue number1
Publication statusPublished - Jan 2015

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