@article{a4390fa4ea1c41c6915721fb9fe121ed,
title = "Grip strength, gait speed, and trajectories of cognitive function in community-dwelling older adults: A prospective study",
abstract = "Introduction: This study investigated whether grip strength and gait speed predict cognitive aging trajectories and examined potential sex-specific associations. Methods: Community-dwelling older adults (n = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, and executive function. Group-based multi-trajectory modeling identified joint cognitive trajectories. Multinomial logistic regression examined the association of grip strength and gait speed at baseline with cognitive trajectories. Results: High performers (14.3%, n = 2298) and low performers (4.0%, n = 642) were compared to the average performers (21.8%, n = 3492). Grip strength and gait speed were positively associated with high performance and negatively with low performance (P-values < 0.01). The association between grip strength and high performance was stronger in women (interaction P < 0.001), while gait speed was a stronger predictor of low performance in men (interaction P < 0.05). Discussion: Grip strength and gait speed are associated with cognitive trajectories in older age, but with sex differences. Highlights: There is inter-individual variability in late-life cognitive trajectories. Grip strength and gait speed predicted cognitive trajectories in older age. However, sex-specific associations were identified. In women, grip strength strongly predicted high, compared to average, trajectory. In men, gait speed was a stronger predictor of low cognitive performance trajectory.",
keywords = "cognitive function, gait speed, grip strength, older adults, prospective",
author = "Zimu Wu and Woods, {Robyn L.} and Chong, {Trevor T.J.} and Orchard, {Suzanne G.} and Shah, {Raj C.} and Rory Wolfe and Elsdon Storey and Sheets, {Kerry M.} and Murray, {Anne M.} and McNeil, {John J.} and Joanne Ryan",
note = "Funding Information: Anne M. Murray reports receiving consulting fees from Alkahest, Inc., grants from the National Institute on Aging, as well as consulting fees and travel fees from Bayer AG to present the primary results of the ASPREE clinical trial. Raj C. Shah reports grants for clinical research regarding dementia and Alzheimer's disease from the National Institutes of Health, the Centers for Medicare and Medicaid Services, the Department of Defense, and the Illinois Department of Public Health; being a non‐compensated member of the Board of Directors of the Alzheimer's Association–Illinois Chapter; and being a site principal investigator or sub‐investigator for clinical trials and research studies for which his institution (Rush University Medical Center) is sponsored (Amylyx Pharmaceuticals, Inc., Athira Pharma, Eli Lilly & Co., Inc., Genentech, Inc., Lundbeck, Inc., Merck & Co, Inc., Navidea Biopharmaceuticals, Novartis Pharmaceuticals, Inc., Roche Holdings AG, and Takeda Development Center Americas, Inc.). Zimu Wu, Robyn L. Woods, Rory Wolfe, Elsdon Storey, Trevor T. J. Chong, John J. McNeil, Kerry M. Sheets, Suzanne G. Orchard, and Joanne Ryan report no competing interest. Author disclosures are available in the supporting information . Funding Information: The authors acknowledge the significant contribution of the dedicated and skilled staff in Australia and the United States to the ASPREE clinical trial. The authors are also most grateful to the ASPREE participants, who so willingly volunteered for this study, and the medical staff and clinics who cared for the participants. The ASPREE clinical trial was supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (U01AG029824 and U19AG062682); the National Health and Medical Research Council (NHMRC) of Australia (334047 and 1127060); Monash University (Australia) and the Victorian Cancer Agency (Australia). Joanne Ryan is funded by an NHMRC Dementia Research Leader Fellowship (APP1135727). Zimu Wu is funded by a Research Training Program scholarship, awarded by Monash University and the Australian government. The funding bodies were not involved in study design; collection, analysis, and interpretation of the data; the writing of the manuscript; or in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",
year = "2023",
month = jan,
day = "1",
doi = "10.1002/dad2.12388",
language = "English",
volume = "15",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "John Wiley & Sons",
number = "1",
}
