Grb10 regulates the development of fiber number in skeletal muscle

Lowenna J Holt; Nigel Turner; Nancy Mokbel; Sophie Trefely; Timo Kanzleiter; Warren Kaplan; Christopher J Ormandy; Roger John Daly; Gregory J Cooney

doi:10.1096/fj.11-199349

Grb10 regulates the development of fiber number in skeletal muscle

Lowenna J Holt, Nigel Turner, Nancy Mokbel, Sophie Trefely, Timo Kanzleiter, Warren Kaplan, Christopher J Ormandy, Roger John Daly, Gregory J Cooney

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

Grb10 is an intracellular adaptor protein that acts as a negative regulator of insulin and insulin-like growth factor 1 (IGF1) receptors. Since global deletion of Grb10 in mice causes hypermuscularity, we have characterized the skeletal muscle physiology underlying this phenotype. Compared to wild-type (WT) controls, adult mice deficient in Grb10 have elevated body mass and muscle mass throughout adulthood, up to 12 mo of age. The muscle enlargement is not due to increased myofiber size, but rather an increase in myofiber number (142 of WT, P

Original language	English
Pages (from-to)	3658 - 3669
Number of pages	12
Journal	The FASEB Journal
Volume	26
Issue number	9
DOIs	https://doi.org/10.1096/fj.11-199349
Publication status	Published - 2012
Externally published	Yes

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Cite this

Holt, L. J., Turner, N., Mokbel, N., Trefely, S., Kanzleiter, T., Kaplan, W., Ormandy, C. J., Daly, R. J., & Cooney, G. J. (2012). Grb10 regulates the development of fiber number in skeletal muscle. The FASEB Journal, 26(9), 3658 - 3669. https://doi.org/10.1096/fj.11-199349

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Grb10 regulates the development of fiber number in skeletal muscle. / Holt, Lowenna J; Turner, Nigel; Mokbel, Nancy; Trefely, Sophie; Kanzleiter, Timo; Kaplan, Warren; Ormandy, Christopher J; Daly, Roger John; Cooney, Gregory J.

In: The FASEB Journal, Vol. 26, No. 9, 2012, p. 3658 - 3669.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Kaplan, Warren

AU - Ormandy, Christopher J

AU - Daly, Roger John

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