Abstract
Grb10 is an intracellular adaptor protein that acts as a negative regulator of insulin and insulin-like growth factor 1 (IGF1) receptors. Since global deletion of Grb10 in mice causes hypermuscularity, we have characterized the skeletal muscle physiology underlying this phenotype. Compared to wild-type (WT) controls, adult mice deficient in Grb10 have elevated body mass and muscle mass throughout adulthood, up to 12 mo of age. The muscle enlargement is not due to increased myofiber size, but rather an increase in myofiber number (142 of WT, P
Original language | English |
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Pages (from-to) | 3658 - 3669 |
Number of pages | 12 |
Journal | The FASEB Journal |
Volume | 26 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2012 |
Externally published | Yes |