Grb10 regulates the development of fiber number in skeletal muscle

Lowenna J Holt, Nigel Turner, Nancy Mokbel, Sophie Trefely, Timo Kanzleiter, Warren Kaplan, Christopher J Ormandy, Roger John Daly, Gregory J Cooney

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27 Citations (Scopus)

Abstract

Grb10 is an intracellular adaptor protein that acts as a negative regulator of insulin and insulin-like growth factor 1 (IGF1) receptors. Since global deletion of Grb10 in mice causes hypermuscularity, we have characterized the skeletal muscle physiology underlying this phenotype. Compared to wild-type (WT) controls, adult mice deficient in Grb10 have elevated body mass and muscle mass throughout adulthood, up to 12 mo of age. The muscle enlargement is not due to increased myofiber size, but rather an increase in myofiber number (142 of WT, P
Original languageEnglish
Pages (from-to)3658 - 3669
Number of pages12
JournalThe FASEB Journal
Volume26
Issue number9
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this

Holt, L. J., Turner, N., Mokbel, N., Trefely, S., Kanzleiter, T., Kaplan, W., Ormandy, C. J., Daly, R. J., & Cooney, G. J. (2012). Grb10 regulates the development of fiber number in skeletal muscle. The FASEB Journal, 26(9), 3658 - 3669. https://doi.org/10.1096/fj.11-199349