Gray matter volume covariance patterns associated with gait speed in older adults

a multi-cohort MRI study

Helena M. Blumen, Lucy L. Brown, Christian Habeck, Gilles Allali, Emmeline Ayers, Olivier Beauchet, Michele Callisaya, Richard B. Lipton, P. S. Mathuranath, Thanh G. Phan, V. G. Pradeep Kumar, Velandai Srikanth, Joe Verghese

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.

Original languageEnglish
Pages (from-to)446-460
Number of pages15
JournalBrain Imaging and Behavior
Volume13
Issue number2
DOIs
Publication statusPublished - 15 Apr 2018

Keywords

  • Cognition
  • Gait
  • Gray matter
  • Magnetic resonance imaging
  • Multivariate analyses

Cite this

Blumen, H. M., Brown, L. L., Habeck, C., Allali, G., Ayers, E., Beauchet, O., ... Verghese, J. (2018). Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study. Brain Imaging and Behavior, 13(2), 446-460. https://doi.org/10.1007/s11682-018-9871-7
Blumen, Helena M. ; Brown, Lucy L. ; Habeck, Christian ; Allali, Gilles ; Ayers, Emmeline ; Beauchet, Olivier ; Callisaya, Michele ; Lipton, Richard B. ; Mathuranath, P. S. ; Phan, Thanh G. ; Pradeep Kumar, V. G. ; Srikanth, Velandai ; Verghese, Joe. / Gray matter volume covariance patterns associated with gait speed in older adults : a multi-cohort MRI study. In: Brain Imaging and Behavior. 2018 ; Vol. 13, No. 2. pp. 446-460.
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abstract = "Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.",
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Blumen, HM, Brown, LL, Habeck, C, Allali, G, Ayers, E, Beauchet, O, Callisaya, M, Lipton, RB, Mathuranath, PS, Phan, TG, Pradeep Kumar, VG, Srikanth, V & Verghese, J 2018, 'Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study', Brain Imaging and Behavior, vol. 13, no. 2, pp. 446-460. https://doi.org/10.1007/s11682-018-9871-7

Gray matter volume covariance patterns associated with gait speed in older adults : a multi-cohort MRI study. / Blumen, Helena M.; Brown, Lucy L.; Habeck, Christian; Allali, Gilles; Ayers, Emmeline; Beauchet, Olivier; Callisaya, Michele; Lipton, Richard B.; Mathuranath, P. S.; Phan, Thanh G.; Pradeep Kumar, V. G.; Srikanth, Velandai; Verghese, Joe.

In: Brain Imaging and Behavior, Vol. 13, No. 2, 15.04.2018, p. 446-460.

Research output: Contribution to journalArticleResearchpeer-review

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T2 - a multi-cohort MRI study

AU - Blumen, Helena M.

AU - Brown, Lucy L.

AU - Habeck, Christian

AU - Allali, Gilles

AU - Ayers, Emmeline

AU - Beauchet, Olivier

AU - Callisaya, Michele

AU - Lipton, Richard B.

AU - Mathuranath, P. S.

AU - Phan, Thanh G.

AU - Pradeep Kumar, V. G.

AU - Srikanth, Velandai

AU - Verghese, Joe

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N2 - Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how they relate to specific cognitive domains, are not well-understood. We examined structural brain correlates of gait speed, and how they relate to processing speed, executive function, and episodic memory in three non-demented and community-dwelling older adult cohorts (Overall N = 352), using voxel-based morphometry and multivariate covariance-based statistics. In all three cohorts, we identified gray matter volume covariance patterns associated with gait speed that included brain stem, precuneus, fusiform, motor, supplementary motor, and prefrontal (particularly ventrolateral prefrontal) cortex regions. Greater expression of these gray matter volume covariance patterns linked to gait speed were associated with better processing speed in all three cohorts, and with better executive function in one cohort. These gray matter covariance patterns linked to gait speed were not associated with episodic memory in any of the cohorts. These findings suggest that gait speed, processing speed (and to some extent executive functions) rely on shared neural systems that are subject to age-related and dementia-related change. The implications of these findings are discussed within the context of the development of interventions to compensate for age-related gait and cognitive decline.

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KW - Cognition

KW - Gait

KW - Gray matter

KW - Magnetic resonance imaging

KW - Multivariate analyses

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