Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies

Emre Bora, Alex Fornito, Christos Pantelis, Murat Yucel

Research output: Contribution to journalArticleResearchpeer-review

399 Citations (Scopus)

Abstract

Voxel-based morphometry (VBM) has been widely used to quantify structural brain changes associated with Major Depressive Disorder (MDD). While some consistent findings have been reported, individual studies have also varied with respect to the key brain regions affected by the illness, and how these abnormalities are related to patients clinical characteristics. Here, we aimed to identify those brain regions that most consistently showed gray matter anomalies in MDD, and their clinical correlates, using meta-analytic techniques.
Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalJournal of Affective Disorders
Volume138
Issue number1-2
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • major depressive disorder
  • MRI
  • voxel-based-morphometry
  • gray matter

Cite this