Projects per year
Abstract
Electroactive materials have been investigated as next-generation neuronal tissue engineering scaffolds to enhance neuronal regeneration and functional recovery after brain injury. Graphene, an emerging neuronal scaffold material with charge transfer properties, has shown promising results for neuronal cell survival and differentiation in vitro. In this in vivo work, electrospun microfiber scaffolds coated with self-assembled colloidal graphene, were implanted into the striatum or into the subventricular zone of adult rats. Microglia and astrocyte activation levels were suppressed with graphene functionalization. In addition, self-assembled graphene implants prevented glial scarring in the brain 7 weeks following implantation. Astrocyte guidance within the scaffold and redirection of neuroblasts from the subventricular zone along the implants was also demonstrated. These findings provide new functional evidence for the potential use of graphene scaffolds as a therapeutic platform to support central nervous system regeneration.
Original language | English |
---|---|
Article number | e0151589 |
Number of pages | 15 |
Journal | PLoS ONE |
Volume | 11 |
Issue number | 3 |
DOIs | |
Publication status | Published - 15 Mar 2016 |
Keywords
- astrocytes
- microglial cells
- inflammation
- microstructure
- neostriatum
- neurobiology of disease and regeneration
- neuronal differentiation
- brain damage
Projects
- 1 Finished
-
Multiple Sclerosis Therapy: Human Pluripotent Stem Cell-derived Neural Progenitor Cells.
Bernard, C., Laslett, A. & O'Brien, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/07/12 → 30/12/16
Project: Research
Equipment
-
Centre for Electron Microscopy (MCEM)
Flame Sorrell (Manager) & Peter Miller (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility