Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis

A. C. Cheng; P. Dasari; Bart J Currie

doi:10.1007/s10096-003-1088-y

Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis

A. C. Cheng
, P. Dasari
, Bart J Currie

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

The study reported here was conducted in order to explore the mechanism of action of granulocyte colony-stimulating factor (G-CSF) in the treatment of Burkholderia pseudomallei infections (otherwise known as melioidosis). Use of G-CSF as an adjunct to antibiotics has been associated with decreasing mortality among patients with melioidosis in the tropical region of the Northern Territory of Australia. However, using an in vitro whole blood assay, no significant difference was detected in the bactericidal activity of samples obtained from dialysis patients, patients with type 2 diabetes mellitus and healthy controls, and there was no improvement following coincubation with G-CSF.

Original language	English
Pages (from-to)	205-207
Number of pages	3
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/s10096-003-1088-y
Publication status	Published - Mar 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1007/s10096-003-1088-y

Cite this

@article{3dd72df78e6a4db9a0e62ea9b458bd03,

title = "Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis",

abstract = "The study reported here was conducted in order to explore the mechanism of action of granulocyte colony-stimulating factor (G-CSF) in the treatment of Burkholderia pseudomallei infections (otherwise known as melioidosis). Use of G-CSF as an adjunct to antibiotics has been associated with decreasing mortality among patients with melioidosis in the tropical region of the Northern Territory of Australia. However, using an in vitro whole blood assay, no significant difference was detected in the bactericidal activity of samples obtained from dialysis patients, patients with type 2 diabetes mellitus and healthy controls, and there was no improvement following coincubation with G-CSF.",

author = "Cheng, \{A. C.\} and P. Dasari and Currie, \{Bart J\}",

year = "2004",

month = mar,

doi = "10.1007/s10096-003-1088-y",

language = "English",

volume = "23",

pages = "205--207",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

issn = "0934-9723",

publisher = "Springer-Verlag London Ltd.",

number = "3",

}

TY - JOUR

T1 - Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis

AU - Cheng, A. C.

AU - Dasari, P.

AU - Currie, Bart J

PY - 2004/3

Y1 - 2004/3

N2 - The study reported here was conducted in order to explore the mechanism of action of granulocyte colony-stimulating factor (G-CSF) in the treatment of Burkholderia pseudomallei infections (otherwise known as melioidosis). Use of G-CSF as an adjunct to antibiotics has been associated with decreasing mortality among patients with melioidosis in the tropical region of the Northern Territory of Australia. However, using an in vitro whole blood assay, no significant difference was detected in the bactericidal activity of samples obtained from dialysis patients, patients with type 2 diabetes mellitus and healthy controls, and there was no improvement following coincubation with G-CSF.

AB - The study reported here was conducted in order to explore the mechanism of action of granulocyte colony-stimulating factor (G-CSF) in the treatment of Burkholderia pseudomallei infections (otherwise known as melioidosis). Use of G-CSF as an adjunct to antibiotics has been associated with decreasing mortality among patients with melioidosis in the tropical region of the Northern Territory of Australia. However, using an in vitro whole blood assay, no significant difference was detected in the bactericidal activity of samples obtained from dialysis patients, patients with type 2 diabetes mellitus and healthy controls, and there was no improvement following coincubation with G-CSF.

UR - https://www.scopus.com/pages/publications/1842638504

U2 - 10.1007/s10096-003-1088-y

DO - 10.1007/s10096-003-1088-y

M3 - Article

C2 - 14986161

AN - SCOPUS:1842638504

SN - 0934-9723

VL - 23

SP - 205

EP - 207

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

IS - 3

ER -

Granulocyte colony-stimulating factor and an in vitro whole blood model of melioidosis

Abstract

UN SDGs

Access to Document

Other files and links

Cite this