GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

Craig McKenzie; Charles R Mackay; Laurence Macia

doi:10.1016/j.tem.2015.07.009

GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

Craig McKenzie, Charles R Mackay, Laurence Macia

Research output: Contribution to journal › Short Survey › Other › peer-review

34 Citations (Scopus)

Abstract

Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.

Original language	English
Pages (from-to)	511-512
Number of pages	2
Journal	Trends in Endocrinology & Metabolism
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2015.07.009
Publication status	Published - Oct 2015

Keywords

fiber
GPR43
Inflammation
metabolism
SCFAs

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10.1016/j.tem.2015.07.009

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title = "GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases",

abstract = "Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.",

keywords = "fiber, GPR43, Inflammation, metabolism, SCFAs",

author = "Craig McKenzie and Mackay, {Charles R} and Laurence Macia",

year = "2015",

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language = "English",

volume = "26",

pages = "511--512",

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TY - JOUR

T1 - GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

AU - McKenzie, Craig

AU - Mackay, Charles R

AU - Macia, Laurence

PY - 2015/10

Y1 - 2015/10

N2 - Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.

AB - Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.

KW - fiber

KW - GPR43

KW - Inflammation

KW - metabolism

KW - SCFAs

UR - http://www.ncbi.nlm.nih.gov/pubmed/26412151

U2 - 10.1016/j.tem.2015.07.009

DO - 10.1016/j.tem.2015.07.009

M3 - Short Survey

SN - 1043-2760

VL - 26

SP - 511

EP - 512

JO - Trends in Endocrinology & Metabolism

JF - Trends in Endocrinology & Metabolism

IS - 10

ER -

GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

Abstract

Keywords

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