GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

    Research output: Contribution to journalShort SurveyOtherpeer-review

    Abstract

    Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.
    Original languageEnglish
    Pages (from-to)511-512
    Number of pages2
    JournalTrends in Endocrinology and Metabolism
    Volume26
    Issue number10
    DOIs
    Publication statusPublished - Oct 2015

    Keywords

    • fiber
    • GPR43
    • Inflammation
    • metabolism
    • SCFAs

    Cite this

    @article{0a74d7bc109c4bf18896e9e491b008d7,
    title = "GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases",
    abstract = "Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.",
    keywords = "fiber, GPR43, Inflammation, metabolism, SCFAs",
    author = "Craig McKenzie and Mackay, {Charles R} and Laurence Macia",
    year = "2015",
    month = "10",
    doi = "10.1016/j.tem.2015.07.009",
    language = "English",
    volume = "26",
    pages = "511--512",
    journal = "Trends in Endocrinology and Metabolism",
    issn = "1043-2760",
    publisher = "Elsevier",
    number = "10",

    }

    GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases. / McKenzie, Craig; Mackay, Charles R; Macia, Laurence.

    In: Trends in Endocrinology and Metabolism, Vol. 26, No. 10, 10.2015, p. 511-512.

    Research output: Contribution to journalShort SurveyOtherpeer-review

    TY - JOUR

    T1 - GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

    AU - McKenzie, Craig

    AU - Mackay, Charles R

    AU - Macia, Laurence

    PY - 2015/10

    Y1 - 2015/10

    N2 - Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.

    AB - Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.

    KW - fiber

    KW - GPR43

    KW - Inflammation

    KW - metabolism

    KW - SCFAs

    UR - http://www.ncbi.nlm.nih.gov/pubmed/26412151

    U2 - 10.1016/j.tem.2015.07.009

    DO - 10.1016/j.tem.2015.07.009

    M3 - Short Survey

    VL - 26

    SP - 511

    EP - 512

    JO - Trends in Endocrinology and Metabolism

    JF - Trends in Endocrinology and Metabolism

    SN - 1043-2760

    IS - 10

    ER -