GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

Craig McKenzie, Charles R Mackay, Laurence Macia

    Research output: Contribution to journalShort SurveyOtherpeer-review

    18 Citations (Scopus)

    Abstract

    Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of Western lifestyle diseases.
    Original languageEnglish
    Pages (from-to)511-512
    Number of pages2
    JournalTrends in Endocrinology & Metabolism
    Volume26
    Issue number10
    DOIs
    Publication statusPublished - Oct 2015

    Keywords

    • fiber
    • GPR43
    • Inflammation
    • metabolism
    • SCFAs

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