Gonadotropin inhibitory hormone (GnIH) as a regulator of gonadotropes

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Abstract

Gonadotropin inhibitory hormone (GnIH) has emerged as a negative regulator of gonadotrope function in a range of species. In rodents, such as rats and mice, GnIH exerts influence upon GnRH cells within the brain. In other species, however, the peptide is secreted into hypophysial portal blood to act on pituitary gonadotropes. In particular, a series of studies in sheep have demonstrated potent actions at the level of the pituitary gland to counteract the function of GnRH in terms of the synthesis and secretion of gonadotropins. This review focuses on the action of GnIH at the level of the gonadotrope.
Original languageEnglish
Pages (from-to)36 - 44
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume385
Issue number1-2
DOIs
Publication statusPublished - 2014

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