Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone)

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.
Original languageEnglish
Title of host publicationEndocrinology
Subtitle of host publicationAdult & Pediatric
EditorsJ Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir
Place of PublicationPhiladelphia PA USA
PublisherElsevier
Pages2037 - 2050
Number of pages14
Volume1 and 2
Edition7th
ISBN (Print)9780323189071
Publication statusPublished - 2016

Cite this

de Kretser, D. M., Hedger, M. P., & Burger, H. G. (2016). Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). In J. L. Jameson, L. J. De Groot, D. M. de Kretser, L. C. Giudice, A. B. Grossman, S. Melmed, J. T. Potts Jr, ... G. C. Weir (Eds.), Endocrinology: Adult & Pediatric (7th ed., Vol. 1 and 2, pp. 2037 - 2050). Philadelphia PA USA: Elsevier.
de Kretser, David M ; Hedger, Mark P ; Burger, Henry G. / Gonadal peptides : Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). Endocrinology: Adult & Pediatric. editor / J Larry Jameson ; Leslie J De Groot ; David M de Kretser ; Linda C Giudice ; Ashley B Grossman ; Shlomo Melmed ; John T Potts Jr ; Gordon C Weir. Vol. 1 and 2 7th. ed. Philadelphia PA USA : Elsevier, 2016. pp. 2037 - 2050
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abstract = "Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.",
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de Kretser, DM, Hedger, MP & Burger, HG 2016, Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). in JL Jameson, LJ De Groot, DM de Kretser, LC Giudice, AB Grossman, S Melmed, JT Potts Jr & GC Weir (eds), Endocrinology: Adult & Pediatric. 7th edn, vol. 1 and 2, Elsevier, Philadelphia PA USA, pp. 2037 - 2050.

Gonadal peptides : Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). / de Kretser, David M; Hedger, Mark P; Burger, Henry G.

Endocrinology: Adult & Pediatric. ed. / J Larry Jameson; Leslie J De Groot; David M de Kretser; Linda C Giudice; Ashley B Grossman; Shlomo Melmed; John T Potts Jr; Gordon C Weir. Vol. 1 and 2 7th. ed. Philadelphia PA USA : Elsevier, 2016. p. 2037 - 2050.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Gonadal peptides

T2 - Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone)

AU - de Kretser, David M

AU - Hedger, Mark P

AU - Burger, Henry G

PY - 2016

Y1 - 2016

N2 - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.

AB - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.

UR - http://www.sciencedirect.com/science/book/9780323189071

UR - http://www.elsevierhealth.com.au/endocrinology-adult-and-pediatric-2-volume-set-9780323189071.html

M3 - Chapter (Book)

SN - 9780323189071

VL - 1 and 2

SP - 2037

EP - 2050

BT - Endocrinology

A2 - Jameson, J Larry

A2 - De Groot, Leslie J

A2 - de Kretser, David M

A2 - Giudice, Linda C

A2 - Grossman, Ashley B

A2 - Melmed, Shlomo

A2 - Potts Jr, John T

A2 - Weir, Gordon C

PB - Elsevier

CY - Philadelphia PA USA

ER -

de Kretser DM, Hedger MP, Burger HG. Gonadal peptides: Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). In Jameson JL, De Groot LJ, de Kretser DM, Giudice LC, Grossman AB, Melmed S, Potts Jr JT, Weir GC, editors, Endocrinology: Adult & Pediatric. 7th ed. Vol. 1 and 2. Philadelphia PA USA: Elsevier. 2016. p. 2037 - 2050