Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone)

David M de Kretser; Mark P Hedger; Henry G Burger

doi:10.1016/B978-0-323-18907-1.00117-7

Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone)

David M de Kretser, Mark P Hedger, Henry G Burger

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

1 Citation (Scopus)

Abstract

Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.

Original language	English
Title of host publication	Endocrinology
Subtitle of host publication	Adult and Pediatric
Editors	J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir
Place of Publication	Philadelphia PA USA
Publisher	Elsevier
Chapter	117
Pages	2037-2050.e6
Number of pages	20
Volume	II
Edition	7th
ISBN (Print)	9780323189071
DOIs	https://doi.org/10.1016/B978-0-323-18907-1.00117-7
Publication status	Published - 2016

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de Kretser, D. M., Hedger, M. P., & Burger, H. G. (2016). Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone). In J. L. Jameson, L. J. De Groot, D. M. de Kretser, L. C. Giudice, A. B. Grossman, S. Melmed, J. T. Potts Jr, & G. C. Weir (Eds.), Endocrinology: Adult and Pediatric (7th ed., Vol. II, pp. 2037-2050.e6). Elsevier. https://doi.org/10.1016/B978-0-323-18907-1.00117-7

de Kretser, David M ; Hedger, Mark P ; Burger, Henry G. / Gonadal Peptides : Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone). Endocrinology: Adult and Pediatric. editor / J Larry Jameson ; Leslie J De Groot ; David M de Kretser ; Linda C Giudice ; Ashley B Grossman ; Shlomo Melmed ; John T Potts Jr ; Gordon C Weir. Vol. II 7th. ed. Philadelphia PA USA : Elsevier, 2016. pp. 2037-2050.e6

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title = "Gonadal Peptides: Inhibins, Activins, Follistatin, and M{\"u}llerian-Inhibiting Substance (Antim{\"u}llerian Hormone)",

abstract = "Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.",

author = "{de Kretser}, {David M} and Hedger, {Mark P} and Burger, {Henry G}",

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de Kretser, DM , Hedger, MP & Burger, HG 2016, Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone). in JL Jameson, LJ De Groot, DM de Kretser, LC Giudice, AB Grossman, S Melmed, JT Potts Jr & GC Weir (eds), Endocrinology: Adult and Pediatric. 7th edn, vol. II, Elsevier, Philadelphia PA USA, pp. 2037-2050.e6. https://doi.org/10.1016/B978-0-323-18907-1.00117-7

Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone). / de Kretser, David M ; Hedger, Mark P; Burger, Henry G.
Endocrinology: Adult and Pediatric. ed. / J Larry Jameson; Leslie J De Groot; David M de Kretser; Linda C Giudice; Ashley B Grossman; Shlomo Melmed; John T Potts Jr; Gordon C Weir. Vol. II 7th. ed. Philadelphia PA USA: Elsevier, 2016. p. 2037-2050.e6.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

TY - CHAP

T1 - Gonadal Peptides

T2 - Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone)

AU - de Kretser, David M

AU - Hedger, Mark P

AU - Burger, Henry G

PY - 2016

Y1 - 2016

N2 - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.

AB - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.

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M3 - Chapter (Book)

SN - 9780323189071

VL - II

SP - 2037-2050.e6

BT - Endocrinology

A2 - Jameson, J Larry

A2 - De Groot, Leslie J

A2 - de Kretser, David M

A2 - Giudice, Linda C

A2 - Grossman, Ashley B

A2 - Melmed, Shlomo

A2 - Potts Jr, John T

A2 - Weir, Gordon C

PB - Elsevier

CY - Philadelphia PA USA

ER -

de Kretser DM , Hedger MP, Burger HG. Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone). In Jameson JL, De Groot LJ, de Kretser DM, Giudice LC, Grossman AB, Melmed S, Potts Jr JT, Weir GC, editors, Endocrinology: Adult and Pediatric. 7th ed. Vol. II. Philadelphia PA USA: Elsevier. 2016. p. 2037-2050.e6 doi: 10.1016/B978-0-323-18907-1.00117-7

Gonadal Peptides: Inhibins, Activins, Follistatin, and Müllerian-Inhibiting Substance (Antimüllerian Hormone)

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