Abstract
| Original language | English |
|---|---|
| Title of host publication | Endocrinology |
| Subtitle of host publication | Adult & Pediatric |
| Editors | J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir |
| Place of Publication | Philadelphia PA USA |
| Publisher | Elsevier |
| Pages | 2037 - 2050 |
| Number of pages | 14 |
| Volume | 1 and 2 |
| Edition | 7th |
| ISBN (Print) | 9780323189071 |
| Publication status | Published - 2016 |
Cite this
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Gonadal peptides : Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone). / de Kretser, David M; Hedger, Mark P; Burger, Henry G.
Endocrinology: Adult & Pediatric. ed. / J Larry Jameson; Leslie J De Groot; David M de Kretser; Linda C Giudice; Ashley B Grossman; Shlomo Melmed; John T Potts Jr; Gordon C Weir. Vol. 1 and 2 7th. ed. Philadelphia PA USA : Elsevier, 2016. p. 2037 - 2050.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Gonadal peptides
T2 - Inhibins, activins, follistatin, and Müllerian-inhibiting substance (Antimüllerian hormone)
AU - de Kretser, David M
AU - Hedger, Mark P
AU - Burger, Henry G
PY - 2016
Y1 - 2016
N2 - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.
AB - Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.
UR - http://www.sciencedirect.com/science/book/9780323189071
UR - http://www.elsevierhealth.com.au/endocrinology-adult-and-pediatric-2-volume-set-9780323189071.html
M3 - Chapter (Book)
SN - 9780323189071
VL - 1 and 2
SP - 2037
EP - 2050
BT - Endocrinology
A2 - Jameson, J Larry
A2 - De Groot, Leslie J
A2 - de Kretser, David M
A2 - Giudice, Linda C
A2 - Grossman, Ashley B
A2 - Melmed, Shlomo
A2 - Potts Jr, John T
A2 - Weir, Gordon C
PB - Elsevier
CY - Philadelphia PA USA
ER -