Abstract
Activins A and B both stimulate FSH secretion, and this and their other actions are modulated by follistatin, a protein that binds the activins virtually irreversibly and thus decreases FSH.- Activin A is a key regulator of the inflammatory response and stimulates fibrosis, and follistatin is thus an antiinflammatory and antifibrotic agent.- Elevated levels of activin A stimulate apoptosis of hepatocytes and B lymphocytes, actions that are all decreased by follistatin.- Follistatin also binds and decreases the actions of other TGF-β proteins, myostatin (GDF8), GDF9, and BMPs 2, 5, 7, and 8.- Mullerian inhibiting substance may be of value as a marker of ovarian follicle reserve and is claimed to assist in predicting the ovarian response to gonadotropin stimulation, a concept requiring further confirmation.
Original language | English |
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Title of host publication | Endocrinology |
Subtitle of host publication | Adult & Pediatric |
Editors | J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir |
Place of Publication | Philadelphia PA USA |
Publisher | Elsevier |
Pages | 2037 - 2050 |
Number of pages | 14 |
Volume | 1 and 2 |
Edition | 7th |
ISBN (Print) | 9780323189071 |
Publication status | Published - 2016 |