Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation

Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Pena Auladell, Laura Fabregas , Nicholas Fletcher, Zachary Houston, Kristofer James Thurecht, Nicolas Hans Voelcker

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy because of their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent, and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to a 1 GHz electromagnetic field (microwave radiation), cell viability significantly decreases, thus demonstrating that Au NCs exhibit specific microwave-dependent cytotoxicity, likely resulting from localized heating. Upon i.v. injection in mice, Au NCs are still present at 24 h post administration. Considering the specific microwave-dependent cytotoxicity and low intrinsic toxicity, our work suggests the potential of Au NCs as effective and safe nanomedicines for cancer therapy.

Original languageEnglish
Pages (from-to)41159-41167
Number of pages9
JournalACS Applied Materials and Interfaces
Volume9
Issue number47
DOIs
Publication statusPublished - 29 Nov 2017

Keywords

  • cytotoxicity
  • electromagnetic radiation
  • gold nanoclusters
  • hyperthermia
  • microwave frequency

Cite this

Cifuentes-Rius, Anna ; Ivask, Angela ; Das, Shreya ; Pena Auladell, Nuria ; Fabregas , Laura ; Fletcher, Nicholas ; Houston, Zachary ; Thurecht, Kristofer James ; Voelcker, Nicolas Hans. / Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation. In: ACS Applied Materials and Interfaces. 2017 ; Vol. 9, No. 47. pp. 41159-41167.
@article{e220b9b240094081b325f133bffa3bf9,
title = "Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation",
abstract = "Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy because of their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent, and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to a 1 GHz electromagnetic field (microwave radiation), cell viability significantly decreases, thus demonstrating that Au NCs exhibit specific microwave-dependent cytotoxicity, likely resulting from localized heating. Upon i.v. injection in mice, Au NCs are still present at 24 h post administration. Considering the specific microwave-dependent cytotoxicity and low intrinsic toxicity, our work suggests the potential of Au NCs as effective and safe nanomedicines for cancer therapy.",
keywords = "cytotoxicity, electromagnetic radiation, gold nanoclusters, hyperthermia, microwave frequency",
author = "Anna Cifuentes-Rius and Angela Ivask and Shreya Das and {Pena Auladell}, Nuria and Laura Fabregas and Nicholas Fletcher and Zachary Houston and Thurecht, {Kristofer James} and Voelcker, {Nicolas Hans}",
year = "2017",
month = "11",
day = "29",
doi = "10.1021/acsami.7b13100",
language = "English",
volume = "9",
pages = "41159--41167",
journal = "ACS Applied Materials and Interfaces",
issn = "1944-8244",
publisher = "ACS Publications",
number = "47",

}

Cifuentes-Rius, A, Ivask, A, Das, S, Pena Auladell, N, Fabregas , L, Fletcher, N, Houston, Z, Thurecht, KJ & Voelcker, NH 2017, 'Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation', ACS Applied Materials and Interfaces, vol. 9, no. 47, pp. 41159-41167. https://doi.org/10.1021/acsami.7b13100

Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation. / Cifuentes-Rius, Anna; Ivask, Angela; Das, Shreya; Pena Auladell, Nuria; Fabregas , Laura; Fletcher, Nicholas; Houston, Zachary; Thurecht, Kristofer James; Voelcker, Nicolas Hans.

In: ACS Applied Materials and Interfaces, Vol. 9, No. 47, 29.11.2017, p. 41159-41167.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation

AU - Cifuentes-Rius, Anna

AU - Ivask, Angela

AU - Das, Shreya

AU - Pena Auladell, Nuria

AU - Fabregas , Laura

AU - Fletcher, Nicholas

AU - Houston, Zachary

AU - Thurecht, Kristofer James

AU - Voelcker, Nicolas Hans

PY - 2017/11/29

Y1 - 2017/11/29

N2 - Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy because of their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent, and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to a 1 GHz electromagnetic field (microwave radiation), cell viability significantly decreases, thus demonstrating that Au NCs exhibit specific microwave-dependent cytotoxicity, likely resulting from localized heating. Upon i.v. injection in mice, Au NCs are still present at 24 h post administration. Considering the specific microwave-dependent cytotoxicity and low intrinsic toxicity, our work suggests the potential of Au NCs as effective and safe nanomedicines for cancer therapy.

AB - Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy because of their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent, and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to a 1 GHz electromagnetic field (microwave radiation), cell viability significantly decreases, thus demonstrating that Au NCs exhibit specific microwave-dependent cytotoxicity, likely resulting from localized heating. Upon i.v. injection in mice, Au NCs are still present at 24 h post administration. Considering the specific microwave-dependent cytotoxicity and low intrinsic toxicity, our work suggests the potential of Au NCs as effective and safe nanomedicines for cancer therapy.

KW - cytotoxicity

KW - electromagnetic radiation

KW - gold nanoclusters

KW - hyperthermia

KW - microwave frequency

UR - http://www.scopus.com/inward/record.url?scp=85036455149&partnerID=8YFLogxK

U2 - 10.1021/acsami.7b13100

DO - 10.1021/acsami.7b13100

M3 - Article

VL - 9

SP - 41159

EP - 41167

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

SN - 1944-8244

IS - 47

ER -