Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Najma Annuria Fithri; Yuao Wu; Gary Cowin; Fahima Akhter; Huong D.N. Tran; Brian Tse; Nicholas Westra van Holthe; Shehzahdi S. Moonshi; Karlheinz Peter; Xiaowei Wang; Nghia P. Truong; Hang Thu Ta

doi:10.1016/j.apmt.2023.101750

Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Najma Annuria Fithri, Yuao Wu, Gary Cowin, Fahima Akhter, Huong D.N. Tran, Brian Tse, Nicholas Westra van Holthe, Shehzahdi S. Moonshi, Karlheinz Peter, Xiaowei Wang, Nghia P. Truong, Hang Thu Ta

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases is crucial to provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) as a robust and powerful probe facilitating triple imaging modalities, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and fluorescence imaging (FLI). Additionally, the antibody tagged AuIONP was utilised to facilitate photothermal thrombolysis, stimulated by the exposure to near-infrared (NIR) laser at 808 nm. In vivo observation of the targeted AuIONP showed a significant increase in MRI T₂*-weighted contrast and up to 3-fold more prominent photoacoustic signal and fluorescence intensity compared to the non-targeted group. Upon exposure to NIR laser at 1.5 W/cm², the localised temperature increase at the clot was observed in the targeted AuIONP treated group, facilitating a significantly higher reduction of thrombus area compared to the non-targeted treated group. Our work offers an innovative theranostic probe with excellent triple modality imaging and thrombolysis.

Original language	English
Article number	101750
Number of pages	14
Journal	Applied Materials Today
Volume	31
DOIs	https://doi.org/10.1016/j.apmt.2023.101750
Publication status	Published - Apr 2023

Keywords

Gold nanoparticle
Iron oxide nanoparticle
Magnetic resonance imaging
Photoacoustic Imaging
Photothermal therapy
Thrombosis

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10.1016/j.apmt.2023.101750Licence: CC BY-NC-ND

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@article{961ff8f4059f447993e51b37a6460575,

title = "Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis",

abstract = "Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases is crucial to provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) as a robust and powerful probe facilitating triple imaging modalities, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and fluorescence imaging (FLI). Additionally, the antibody tagged AuIONP was utilised to facilitate photothermal thrombolysis, stimulated by the exposure to near-infrared (NIR) laser at 808 nm. In vivo observation of the targeted AuIONP showed a significant increase in MRI T2*-weighted contrast and up to 3-fold more prominent photoacoustic signal and fluorescence intensity compared to the non-targeted group. Upon exposure to NIR laser at 1.5 W/cm2, the localised temperature increase at the clot was observed in the targeted AuIONP treated group, facilitating a significantly higher reduction of thrombus area compared to the non-targeted treated group. Our work offers an innovative theranostic probe with excellent triple modality imaging and thrombolysis.",

keywords = "Gold nanoparticle, Iron oxide nanoparticle, Magnetic resonance imaging, Photoacoustic Imaging, Photothermal therapy, Thrombosis",

author = "Fithri, {Najma Annuria} and Yuao Wu and Gary Cowin and Fahima Akhter and Tran, {Huong D.N.} and Brian Tse and {van Holthe}, {Nicholas Westra} and Moonshi, {Shehzahdi S.} and Karlheinz Peter and Xiaowei Wang and Truong, {Nghia P.} and Ta, {Hang Thu}",

note = "Funding Information: N.A.F. acknowledges the financial support in the form of PhD scholarship funded by Australia Awards Program. H.T.T and N.P.T . acknowledge the funding support of an Ideas grant ( APP2002827 ) from the National Health and Medical Research Council . H.T.T is supported by a Heart Foundation Future Leader Fellowship ( 102761 ) and NHMRC grants ( APP1037310, APP1182347 ). N.P.T. is grateful for the award of a DECRA Fellowship ( DE180100076 ) and a Discovery Project grant ( DP200100231 ) from the Australian Research Council. K.P is supported by an NHMRC Investigator Fellowship . X.W is supported by a National Heart Foundation Future Leader Fellowship and a Baker Fellowship. Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = apr,

doi = "10.1016/j.apmt.2023.101750",

language = "English",

volume = "31",

journal = "Applied Materials Today",

issn = "2352-9407",

publisher = "Elsevier BV",

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T1 - Gold-iron oxide nanoparticle

T2 - A unique multimodal theranostic approach for thrombosis

AU - Fithri, Najma Annuria

AU - Wu, Yuao

AU - Cowin, Gary

AU - Akhter, Fahima

AU - Tran, Huong D.N.

AU - Tse, Brian

AU - van Holthe, Nicholas Westra

AU - Moonshi, Shehzahdi S.

AU - Peter, Karlheinz

AU - Wang, Xiaowei

AU - Truong, Nghia P.

AU - Ta, Hang Thu

N1 - Funding Information: N.A.F. acknowledges the financial support in the form of PhD scholarship funded by Australia Awards Program. H.T.T and N.P.T . acknowledge the funding support of an Ideas grant ( APP2002827 ) from the National Health and Medical Research Council . H.T.T is supported by a Heart Foundation Future Leader Fellowship ( 102761 ) and NHMRC grants ( APP1037310, APP1182347 ). N.P.T. is grateful for the award of a DECRA Fellowship ( DE180100076 ) and a Discovery Project grant ( DP200100231 ) from the Australian Research Council. K.P is supported by an NHMRC Investigator Fellowship . X.W is supported by a National Heart Foundation Future Leader Fellowship and a Baker Fellowship. Publisher Copyright: © 2023 The Author(s)

PY - 2023/4

Y1 - 2023/4

N2 - Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases is crucial to provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) as a robust and powerful probe facilitating triple imaging modalities, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and fluorescence imaging (FLI). Additionally, the antibody tagged AuIONP was utilised to facilitate photothermal thrombolysis, stimulated by the exposure to near-infrared (NIR) laser at 808 nm. In vivo observation of the targeted AuIONP showed a significant increase in MRI T2*-weighted contrast and up to 3-fold more prominent photoacoustic signal and fluorescence intensity compared to the non-targeted group. Upon exposure to NIR laser at 1.5 W/cm2, the localised temperature increase at the clot was observed in the targeted AuIONP treated group, facilitating a significantly higher reduction of thrombus area compared to the non-targeted treated group. Our work offers an innovative theranostic probe with excellent triple modality imaging and thrombolysis.

AB - Thrombosis is a major concern worldwide as thrombosis-related deaths are attributed to one in five deaths globally. Establishing a clot-targeting theranostic particle for diagnosis and treatment of thrombosis related diseases is crucial to provide rapid life-saving intervention. Herein, we developed activated platelet targeted gold-iron oxide nanoparticles (AuIONP) as a robust and powerful probe facilitating triple imaging modalities, including magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and fluorescence imaging (FLI). Additionally, the antibody tagged AuIONP was utilised to facilitate photothermal thrombolysis, stimulated by the exposure to near-infrared (NIR) laser at 808 nm. In vivo observation of the targeted AuIONP showed a significant increase in MRI T2*-weighted contrast and up to 3-fold more prominent photoacoustic signal and fluorescence intensity compared to the non-targeted group. Upon exposure to NIR laser at 1.5 W/cm2, the localised temperature increase at the clot was observed in the targeted AuIONP treated group, facilitating a significantly higher reduction of thrombus area compared to the non-targeted treated group. Our work offers an innovative theranostic probe with excellent triple modality imaging and thrombolysis.

KW - Gold nanoparticle

KW - Iron oxide nanoparticle

KW - Magnetic resonance imaging

KW - Photoacoustic Imaging

KW - Photothermal therapy

KW - Thrombosis

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U2 - 10.1016/j.apmt.2023.101750

DO - 10.1016/j.apmt.2023.101750

M3 - Article

AN - SCOPUS:85147912383

SN - 2352-9407

VL - 31

JO - Applied Materials Today

JF - Applied Materials Today

M1 - 101750

ER -

Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Abstract

Keywords

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Other files and links

Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis

Bespoke nanomaterials for understanding nano-bio interactions under flow

Scalable synthesis of smart nanoworms with tailored properties

Cite this

Gold-iron oxide nanoparticle: A unique multimodal theranostic approach for thrombosis

Abstract

Keywords

Access to Document

Other files and links

Projects

Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis

Bespoke nanomaterials for understanding nano-bio interactions under flow

Scalable synthesis of smart nanoworms with tailored properties

Cite this