Gold-Catalyzed Cycloisomerizations of 1,n-Diyne Carbonates and Esters

David Philip Day, Philip Wai Hong Chan

Research output: Contribution to journalReview ArticleResearchpeer-review

96 Citations (Scopus)

Abstract

Driven by the ever-growing need for efficient methods to prepare synthetically valuable complex molecules, homogeneous gold catalysis has emerged as an invaluable addition in the organic chemist's toolbox to achieve such goals. Within this field of catalysis, this review focuses on the contributions made toward the construction of core structural scaffolds found in bioactive natural products and pharmaceutical compounds from gold-catalyzed reactions of 1,n-diyne carbonates and esters. It covers the advances made through exploiting the reactivity of the substrate class triggered by an initial 1,2- or 1,3-acyloxy migration of the propargyl motif as well as one rare example of a concerted double cyclization pathway.

Original languageEnglish
Pages (from-to)1368-1384
Number of pages17
JournalAdvanced Synthesis and Catalysis
Volume358
Issue number9
DOIs
Publication statusPublished - 28 Apr 2016

Keywords

  • alkynes
  • cyclization
  • gold
  • homogeneous catalysis
  • synthetic methods

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