Abstract
A synthetic approach that provides access to ciscyclohepta-4,8-diene-fused pyrrolidines efficiently through AuI-catalyzed cycloisomerization of 1,6,8-dienyne carbonates and esters at a low catalyst loading of 2 mol% is reported. Starting carbonates and esters with a pendant alkyl group on the terminal alkenyl carbon center were found to favor tandem 1,2-acyloxy migration/cyclopropanation followed by Cope rearrangement of the resulting cis-3-azabicyclo- [3.1.0]hexane intermediate. On the other hand, substrates containing a terminal diene or starting materials in which the distal alkene moiety bears a phenyl substituent were observed to undergo competitive but reversible 1,3-acyloxy migration prior to the nitrogen-containing bicyclic ring formation. The delineated reaction mechanism also provides experimental evidence for the reversible interconversion between the oft-proposed organogold intermediates obtained in this step of the tandem process.
Original language | English |
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Pages (from-to) | 13174 - 13180 |
Number of pages | 7 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 41 |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Keywords
- Gold
- gold catalysis
- Catalysis