Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles

Xiaoyu Chen; Corentin Antoine Baratay; Maddison Elizabeth Mark; Xinfang Xu; Philip Wai Hong Chan

doi:10.1021/acs.orglett.0c00929

Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles

Xiaoyu Chen, Corentin Antoine Baratay, Maddison Elizabeth Mark, Xinfang Xu, Philip Wai Hong Chan

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Brønsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.

Original language	English
Pages (from-to)	2849-2853
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	7
DOIs	https://doi.org/10.1021/acs.orglett.0c00929
Publication status	Published - 3 Apr 2020

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10.1021/acs.orglett.0c00929

301763891-oaAccepted author manuscript, 476 KBLicence: Unspecified

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title = "Gold and Br{\o}nsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles",

abstract = "A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Br{\o}nsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.",

author = "Xiaoyu Chen and Baratay, {Corentin Antoine} and Mark, {Maddison Elizabeth} and Xinfang Xu and {Hong Chan}, {Philip Wai}",

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doi = "10.1021/acs.orglett.0c00929",

language = "English",

volume = "22",

pages = "2849--2853",

journal = "Organic Letters",

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T1 - Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles

AU - Chen, Xiaoyu

AU - Baratay, Corentin Antoine

AU - Mark, Maddison Elizabeth

AU - Xu, Xinfang

AU - Hong Chan, Philip Wai

PY - 2020/4/3

Y1 - 2020/4/3

N2 - A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Brønsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.

AB - A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Brønsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.

UR - http://www.scopus.com/inward/record.url?scp=85082535994&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.0c00929

DO - 10.1021/acs.orglett.0c00929

M3 - Article

AN - SCOPUS:85082535994

SN - 1523-7060

VL - 22

SP - 2849

EP - 2853

JO - Organic Letters

JF - Organic Letters

IS - 7

ER -

Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles

Abstract

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New Efficient Alkyne Cyclization Strategies for Complex Molecule Synthesis

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Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4, n]alkyl[ b]indoles

Abstract

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New Efficient Alkyne Cyclization Strategies for Complex Molecule Synthesis

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