Goal-directed resuscitation for patients with early septic shock

Research output: Contribution to journalArticleResearchpeer-review

1141 Citations (Scopus)


Background: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. Results: Of the 1600 enrolled patients, 796 were assigned to the EGDT group and 804 to the usual-care group. Primary outcome data were available for more than 99 of the patients. Patients in the EGDT group received a larger mean (?SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964?1415 ml vs. 1713?1401 ml) and were more likely to receive vasopressor infusions (66.6 vs. 57.8 ), red-cell transfusions (13.6 vs. 7.0 ), and dobutamine (15.4 vs. 2.6 ) (P
Original languageEnglish
Pages (from-to)1496 - 1506
Number of pages11
JournalThe New England Journal of Medicine
Issue number16
Publication statusPublished - 2014

Cite this