Goal-directed resuscitation for patients with early septic shock

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Abstract

Background: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. Results: Of the 1600 enrolled patients, 796 were assigned to the EGDT group and 804 to the usual-care group. Primary outcome data were available for more than 99 of the patients. Patients in the EGDT group received a larger mean (?SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964?1415 ml vs. 1713?1401 ml) and were more likely to receive vasopressor infusions (66.6 vs. 57.8 ), red-cell transfusions (13.6 vs. 7.0 ), and dobutamine (15.4 vs. 2.6 ) (P
Original languageEnglish
Pages (from-to)1496 - 1506
Number of pages11
JournalNew England Journal of Medicine
Volume371
Issue number16
DOIs
Publication statusPublished - 2014

Cite this

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title = "Goal-directed resuscitation for patients with early septic shock",
abstract = "Background: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. Results: Of the 1600 enrolled patients, 796 were assigned to the EGDT group and 804 to the usual-care group. Primary outcome data were available for more than 99 of the patients. Patients in the EGDT group received a larger mean (?SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964?1415 ml vs. 1713?1401 ml) and were more likely to receive vasopressor infusions (66.6 vs. 57.8 ), red-cell transfusions (13.6 vs. 7.0 ), and dobutamine (15.4 vs. 2.6 ) (P",
author = "Peake, {Sandra Lois} and Anthony Delaney and Bailey, {Michael John} and Rinaldo Bellomo and Peter Cameron and Cooper, {David James} and Alisa Higgins and Anna Holdgate and Howe, {Belinda Duval} and Webb, {Steven A R} and Patricia Williams",
year = "2014",
doi = "10.1056/NEJMoa1404380",
language = "English",
volume = "371",
pages = "1496 -- 1506",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachusetts Medical Society",
number = "16",

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TY - JOUR

T1 - Goal-directed resuscitation for patients with early septic shock

AU - Peake, Sandra Lois

AU - Delaney, Anthony

AU - Bailey, Michael John

AU - Bellomo, Rinaldo

AU - Cameron, Peter

AU - Cooper, David James

AU - Higgins, Alisa

AU - Holdgate, Anna

AU - Howe, Belinda Duval

AU - Webb, Steven A R

AU - Williams, Patricia

PY - 2014

Y1 - 2014

N2 - Background: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. Results: Of the 1600 enrolled patients, 796 were assigned to the EGDT group and 804 to the usual-care group. Primary outcome data were available for more than 99 of the patients. Patients in the EGDT group received a larger mean (?SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964?1415 ml vs. 1713?1401 ml) and were more likely to receive vasopressor infusions (66.6 vs. 57.8 ), red-cell transfusions (13.6 vs. 7.0 ), and dobutamine (15.4 vs. 2.6 ) (P

AB - Background: Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness is uncertain. Results: Of the 1600 enrolled patients, 796 were assigned to the EGDT group and 804 to the usual-care group. Primary outcome data were available for more than 99 of the patients. Patients in the EGDT group received a larger mean (?SD) volume of intravenous fluids in the first 6 hours after randomization than did those in the usual-care group (1964?1415 ml vs. 1713?1401 ml) and were more likely to receive vasopressor infusions (66.6 vs. 57.8 ), red-cell transfusions (13.6 vs. 7.0 ), and dobutamine (15.4 vs. 2.6 ) (P

UR - http://www.nejm.org/doi/pdf/10.1056/NEJMoa1404380

U2 - 10.1056/NEJMoa1404380

DO - 10.1056/NEJMoa1404380

M3 - Article

VL - 371

SP - 1496

EP - 1506

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 16

ER -