Glycopolymer conjugates

Ahmed M. Eissa, Neil R. Cameron

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

29 Citations (Scopus)

Abstract

This review describes recent developments in the field of glycopolymer (polymer-carbohydrate conjugate) synthesis. The interest in this class of polymers that have a wide range of biological recognition properties has grown rapidly in the last decade due to their application in the areas of biotechnology and medicinal chemistry. Modern synthetic methodologies such as controlled radical polymerization, ionic polymerization, ring-opening polymerization (ROP), ring-opening metathesis polymerization (ROMP) and Click chemistry have recently been proven to be extremely efficient and versatile tools for building tailor-made functional polymers with different molecular architectures. The use of these synthetic methods to prepare glycopolymer conjugates is outlined and discussed in detail. The self-assembling behavior of these glycopolymer designs and their interactions with their corresponding lectins (cell surface receptor proteins) are also presented in this review.

Original languageEnglish
Title of host publicationBio-synthetic Polymer Conjugates
EditorsHelmut Schlaad
Place of PublicationHeidelberg
PublisherSpringer
Pages71-114
Number of pages44
ISBN (Electronic)9783642343506
ISBN (Print)9783642343490
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameAdvances in Polymer Science
PublisherSpringer New York LLC
Volume253
ISSN (Print)0065-3195
ISSN (Electronic)1436-5030

Keywords

  • Binding interactions
  • Biological functions
  • Biopolymers
  • Glycopolymers
  • Glycosides
  • Living polymerization
  • Polymer conjugates
  • Self-assembly

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